EFNB2, ephrin B2

EFNB2, ephrin B2

• This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]

• Gene Synonyms (EPLG5, HTKL, Htk-L, LERK5, ephrin-B2, HTK ligand, eph-related receptor tyrosine kinase ligand 5, ligand of eph-related kinase 5,)
• NCBI Gene ID: 1948
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P52799
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ephrin B2 interacts with:

• aladin WD repeat nucleoporin
  ankyrin repeat domain 46
  cullin associated and neddylation dissociated 2 (putative)
  DENN domain containing 6A
  disco interacting protein 2 homolog A
  disco interacting protein 2 homolog B
  dynamin 3
  eEF1A lysine and N-terminal methyltransferase
  EPH receptor A3
  EPH receptor A4
  EPH receptor A5
  EPH receptor B1
  EPH receptor B2
  EPH receptor B3
  EPH receptor B4
  EPH receptor B6
  ephrin B2
  eukaryotic translation initiation factor 2B subunit beta
  eukaryotic translation initiation factor 2B subunit delta
  eukaryotic translation initiation factor 2B subunit epsilon
  family with sequence similarity 120A
  family with sequence similarity 171 member A2
  glutamate metabotropic receptor 1
  glutamate metabotropic receptor 5
  glutamate receptor interacting protein 1
  heterogeneous nuclear ribonucleoprotein L
  homer scaffold protein 1
  HPS3 biogenesis of lysosomal organelles complex 2 subunit 1
  HRas proto-oncogene, GTPase
  kinesin family member 14
  KRAS proto-oncogene, GTPase
  limb development membrane protein 1
  malic enzyme 1
  MAP7 domain containing 2
  MAP7 domain containing 3
  mediator complex subunit 16
  myotubularin related protein 1
  NCK adaptor protein 2
  neurofibromin 1
  NRAS proto-oncogene, GTPase
  NUS1 dehydrodolichyl diphosphate synthase subunit
  PDZ domain containing ring finger 3
  PH domain and leucine rich repeat protein phosphatase 1
  phosphatidylinositol 4-kinase type 2 beta
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  phosphoinositide-3-kinase regulatory subunit 3
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  plakophilin 2
  platelet and endothelial cell adhesion molecule 1
  pleckstrin homology and RhoGEF domain containing G4
  pleckstrin homology, MyTH4 and FERM domain containing H3
  POM121 transmembrane nucleoporin
  presenilin 1
  protein interacting with PRKCA 1
  protein kinase N3
  protein only RNase P catalytic subunit
  protein tyrosine phosphatase non-receptor type 13
  Rap associating with DIL domain
  reelin
  regulator of G protein signaling 3
  retinol saturase
  rhomboid 5 homolog 2
  rhomboid like 2
  serum amyloid A like 1
  SET binding factor 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  syndecan 2
  syndecan 3
  syndecan binding protein
  testis expressed 2
  tetraspanin 3
  tigger transposable element derived 5
  transmembrane protein 17
  transmembrane protein 216
  tyrosine kinase 2
  ubiquitin protein ligase E3C
  USO1 vesicle transport factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.