EIF2S1, eukaryotic translation initiation factor 2 subunit alpha

EIF2S1, eukaryotic translation initiation factor 2 subunit alpha

• The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

• Gene Synonyms (EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, eukaryotic translation initiation factor 2 subunit 1, eIF-2-alpha, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa,)
• NCBI Gene ID: 1965
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P05198
  UNIPROT ID#>>Q53XC0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation initiation factor 2 subunit alpha interacts with:

• AAR2 splicing factor
  aminoacyl tRNA synthetase complex interacting multifunctional protein 1
  Bet1 golgi vesicular membrane trafficking protein
  bromodomain containing 7
  cap methyltransferase 1
  cell division cycle 37, HSP90 cochaperone
  cell division cycle 73
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  cullin associated and neddylation dissociated 1
  deoxynucleotidyltransferase terminal interacting protein 1
  DExD/H-box helicase 60
  dynamin 1 like
  ELAV like RNA binding protein 1
  elongation factor Tu GTP binding domain containing 2
  estrogen receptor 2
  ETS transcription factor ERG
  eukaryotic translation elongation factor 1 epsilon 1
  eukaryotic translation initiation factor 1B
  eukaryotic translation initiation factor 2 alpha kinase 1
  eukaryotic translation initiation factor 2 alpha kinase 2
  eukaryotic translation initiation factor 2 alpha kinase 3
  eukaryotic translation initiation factor 2 subunit beta
  eukaryotic translation initiation factor 2 subunit gamma
  eukaryotic translation initiation factor 2 subunit gamma B
  eukaryotic translation initiation factor 2B subunit alpha
  eukaryotic translation initiation factor 2B subunit beta
  eukaryotic translation initiation factor 2B subunit delta
  eukaryotic translation initiation factor 2B subunit gamma
  eukaryotic translation initiation factor 5
  eukaryotic translation termination factor 1
  EWS RNA binding protein 1
  exportin 1
  fibronectin 1
  glutaminyl-tRNA synthetase 1
  heat shock protein 90 alpha family class A member 1
  heat shock protein family B (small) member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heparin binding growth factor
  HEXIM P-TEFb complex subunit 1
  integrin subunit alpha 4
  KRAS proto-oncogene, GTPase
  limb development membrane protein 1 like
  mab-21 like 2
  maternal embryonic leucine zipper kinase
  metadherin
  methionyl-tRNA synthetase 1
  microtubule associated protein 4
  microtubule associated serine/threonine kinase 3
  MMS19 homolog, cytosolic iron-sulfur assembly component
  MYC proto-oncogene, bHLH transcription factor
  neurotrophic receptor tyrosine kinase 1
  nuclear receptor coactivator 5
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  nucleophosmin 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  POP1 homolog, ribonuclease P/MRP subunit
  pre-mRNA processing factor 8
  prohibitin
  prolyl 4-hydroxylase subunit beta
  protein arginine methyltransferase 5
  protein arginine methyltransferase 7
  protein kinase C alpha
  protein kinase C delta
  protein phosphatase 1 regulatory subunit 15A
  protein tyrosine phosphatase non-receptor type 2
  PTEN induced kinase 1
  pyruvate dehydrogenase E1 subunit alpha 1
  RAB11A, member RAS oncogene family
  RAD21 cohesin complex component
  RE1 silencing transcription factor
  RecQ like helicase 4
  replication protein A1
  replication protein A2
  replication protein A3
  ribophorin I
  ribosomal protein L13
  ribosomal protein L15
  ribosomal protein L27a
  ribosomal protein L35
  ribosomal protein L7a
  ribosomal protein lateral stalk subunit P0
  ribosomal protein S27 like
  ribosome binding protein 1
  ring finger protein 2
  RIO kinase 1
  RNA polymerase II subunit G
  small nuclear ribonucleoprotein U1 subunit 70
  spindle apparatus coiled-coil protein 1
  staufen double-stranded RNA binding protein 1
  stratifin
  striatin
  succinate dehydrogenase complex flavoprotein subunit A
  superoxide dismutase 1
  synoviolin 1
  target of EGR1, exonuclease
  telomerase reverse transcriptase
  THAP domain containing 12
  TNFAIP3 interacting protein 2
  transmembrane p24 trafficking protein 9
  tripartite motif containing 14
  tripartite motif containing 28
  ubiquitin specific peptidase 14
  UPF1 RNA helicase and ATPase
  VAC14 component of PIKFYVE complex
  vascular cell adhesion molecule 1
  WW domain containing E3 ubiquitin protein ligase 2
  Y-box binding protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.