EPAS1, endothelial PAS domain protein 1

EPAS1, endothelial PAS domain protein 1

• This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]

• Gene Synonyms (ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain-containing protein 1, EPAS-1, HIF-1-alpha-like factor, HIF-1alpha-like factor, HIF-2-alpha, HIF2-alpha, PAS domain-containing protein 2, basic-helix-loop-helix-PAS protein MOP2, class E basic helix-loop-helix protein 73, hypoxia-inducible factor 2 alpha, member of PAS protein 2,)
• NCBI Gene ID: 2034
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99814
  UNIPROT ID#>>B3KW07
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

endothelial PAS domain protein 1 interacts with:

• A-kinase anchoring protein 8 like
  aryl hydrocarbon receptor nuclear translocator
  aryl hydrocarbon receptor nuclear translocator 2
  aryl hydrocarbon receptor nuclear translocator like 2
  AT-rich interaction domain 1B
  BAF chromatin remodeling complex subunit BCL7C
  BAG cochaperone 2
  basic leucine zipper ATF-like transcription factor
  basic leucine zipper ATF-like transcription factor 2
  basic leucine zipper ATF-like transcription factor 3
  cAMP responsive element binding protein 3 like 1
  CCR4-NOT transcription complex subunit 1
  CCR4-NOT transcription complex subunit 10
  CCR4-NOT transcription complex subunit 7
  coagulation factor XII
  CREB binding protein
  DDB1 and CUL4 associated factor 7
  DnaJ heat shock protein family (Hsp40) member A2
  double PHD fingers 2
  dpy-30 histone methyltransferase complex regulatory subunit
  egl-9 family hypoxia inducible factor 1
  egl-9 family hypoxia inducible factor 2
  egl-9 family hypoxia inducible factor 3
  elongator complex protein 1
  elongin B
  endothelial PAS domain protein 1
  estrogen receptor 1
  ETS proto-oncogene 1, transcription factor
  ETS variant transcription factor 4
  eukaryotic translation initiation factor 3 subunit E
  EWS RNA binding protein 1
  exportin 1
  general transcription factor IIIC subunit 3
  heat shock protein 90 alpha family class A member 1
  heat shock protein family A (Hsp70) member 4
  hypoxia inducible factor 1 subunit alpha
  hypoxia inducible factor 3 subunit alpha
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inhibitor of nuclear factor kappa B kinase subunit beta
  intercellular adhesion molecule 1
  Jun proto-oncogene, AP-1 transcription factor subunit
  karyopherin subunit alpha 1
  karyopherin subunit alpha 3
  karyopherin subunit alpha 5
  karyopherin subunit alpha 6
  karyopherin subunit beta 1
  kelch like family member 20
  lysine demethylase 1A
  lysosomal associated membrane protein 1
  mediator complex subunit 1
  mediator complex subunit 10
  mediator complex subunit 11
  mediator complex subunit 12
  mediator complex subunit 14
  mediator complex subunit 15
  mediator complex subunit 16
  mediator complex subunit 17
  mediator complex subunit 18
  mediator complex subunit 20
  mediator complex subunit 22
  mediator complex subunit 23
  mediator complex subunit 24
  mediator complex subunit 25
  mediator complex subunit 26
  mediator complex subunit 27
  mediator complex subunit 29
  mediator complex subunit 4
  mediator complex subunit 7
  mediator complex subunit 8
  melanocyte inducing transcription factor
  microtubule associated protein 1 light chain 3 alpha
  minichromosome maintenance complex component 3
  minichromosome maintenance complex component 7
  MYB proto-oncogene like 2
  MYC associated factor X
  myocyte enhancer factor 2C
  necdin, MAGE family member
  non-SMC condensin II complex subunit D3
  nuclear receptor subfamily 3 group C member 1
  nucleophosmin 1
  prohibitin
  prohibitin 2
  proteasome 20S subunit beta 1
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, non-ATPase 1
  protein kinase D1
  protein tyrosine kinase 6
  RuvB-like protein 1
  secreted phosphoprotein 1
  sequestosome 1
  signal transducer and activator of transcription 5A
  SIN3 transcription regulator family member A
  single stranded DNA binding protein 3
  sirtuin 1
  SMAD family member 3
  Sp1 transcription factor
  SRY-box transcription factor 10
  STIP1 homology and U-box containing protein 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  TERF2 interacting protein
  tet methylcytosine dioxygenase 1
  transcription factor AP-2 alpha
  tripartite motif containing 25
  tripartite motif containing 33
  ubiquitin C
  ubiquitin specific peptidase 20
  upstream transcription factor 2, c-fos interacting
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  WD repeat domain 5
  WRN helicase interacting protein 1
  YTH N6-methyladenosine RNA binding protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.