ERCC1, ERCC excision repair 1, endonuclease non-catalytic subunit

ERCC1, ERCC excision repair 1, endonuclease non-catalytic subunit

• The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

• Gene Synonyms (COFS4, RAD10, UV20, DNA excision repair protein ERCC-1, excision repair cross-complementation group 1, excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence),)
• NCBI Gene ID: 2067
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P07992
  UNIPROT ID#>>A0A024R0Q6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ERCC excision repair 1, endonuclease non-catalytic subunit interacts with:

• chromosome 15 open reading frame 40
  DNA topoisomerase II binding protein 1
  ERCC excision repair 1, endonuclease non-catalytic subunit
  ERCC excision repair 4, endonuclease catalytic subunit
  FA complementation group G
  general transcription factor IIH subunit 1
  growth arrest specific 8
  kinesin family member 11
  MAGI family member, X-linked
  makorin ring finger protein 3
  mediator of DNA damage checkpoint 1
  mitotic arrest deficient 2 like 1
  MUS81 structure-specific endonuclease subunit
  mutS homolog 2
  RAD52 homolog, DNA repair protein
  replication protein A1
  replication protein A2
  replication protein A3
  RNA polymerase II subunit A
  SLX1 homolog A, structure-specific endonuclease subunit
  SLX1 homolog B, structure-specific endonuclease subunit
  SLX4 interacting protein
  SLX4 structure-specific endonuclease subunit
  spectrin alpha, erythrocytic 1
  spindle apparatus coiled-coil protein 1
  TATA-box binding protein
  TATA-box binding protein associated factor 10
  TATA-box binding protein associated factor 12
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 7
  tRNA methyltransferase 2 homolog B
  tumor protein p53 binding protein 1
  twinfilin actin binding protein 2
  ubiquitin like 7
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin specific peptidase 45
  USH1 protein network component harmonin binding protein 1
  VPS37B subunit of ESCRT-I
  XPA, DNA damage recognition and repair factor
  zinc finger C3H1-type containing

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.