ERCC2, ERCC excision repair 2, TFIIH core complex helicase subunit

ERCC2, ERCC excision repair 2, TFIIH core complex helicase subunit

• The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

• Gene Synonyms (COFS2, EM9, TFIIH, TTD, TTD1, XPD, general transcription and DNA repair factor IIH helicase subunit XPD, BTF2 p80, CXPD, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, TFIIH 80 kDa subunit, TFIIH basal transcription factor complex 80 kDa subunit, TFIIH basal transcription factor complex helicase XPB subunit, TFIIH basal transcription factor complex helicase XPD subunit, TFIIH basal transcription factor complex helicase subunit, TFIIH p80, TFIIH subunit XPD, basic transcription factor 2 80 kDa subunit, excision repair cross-complementation group 2, excision repair cross-complementing rodent repair deficiency, complementation group 2, xeroderma pigmentosum complementary group D, xeroderma pigmentosum group D-complementing protein,)
• NCBI Gene ID: 2068
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P18074
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ERCC excision repair 2, TFIIH core complex helicase subunit interacts with:

• activating transcription factor 7 interacting protein
  clustered mitochondria homolog
  cytosolic iron-sulfur assembly component 1
  cytosolic iron-sulfur assembly component 2B
  DNA topoisomerase II binding protein 1
  ERCC excision repair 2, TFIIH core complex helicase subunit
  ERCC excision repair 3, TFIIH core complex helicase subunit
  ERCC excision repair 5, endonuclease
  ERCC excision repair 6, chromatin remodeling factor
  estrogen receptor 2
  eukaryotic translation initiation factor 2A
  exportin 1
  general transcription factor IIF subunit 1
  general transcription factor IIH subunit 1
  general transcription factor IIH subunit 2
  general transcription factor IIH subunit 3
  general transcription factor IIH subunit 5
  GTF2H2 family member C, copy 2
  HECT and RLD domain containing E3 ubiquitin protein ligase 5
  ISG15 ubiquitin like modifier
  KRAS proto-oncogene, GTPase
  metadherin
  mitotic arrest deficient 2 like 1
  MMS19 homolog, cytosolic iron-sulfur assembly component
  MNAT1 component of CDK activating kinase
  neurotrophic receptor tyrosine kinase 1
  nuclear receptor subfamily 2 group C member 2
  p53-induced death domain protein 1
  pleckstrin homology domain containing A4
  RAD51 recombinase
  RAD52 homolog, DNA repair protein
  spectrin alpha, erythrocytic 1
  tripartite motif containing 25
  tripartite motif containing 28
  tumor protein p53
  ubiquitin like with PHD and ring finger domains 2
  UV stimulated scaffold protein A
  WD repeat domain 61
  XPA, DNA damage recognition and repair factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.