ERCC3, ERCC excision repair 3, TFIIH core complex helicase subunit

ERCC3, ERCC excision repair 3, TFIIH core complex helicase subunit

• This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

• Gene Synonyms (BTF2, GTF2H, RAD25, TFIIH, TTD2, XPB, general transcription and DNA repair factor IIH helicase subunit XPB, BTF2 p89, DNA excision repair protein ERCC-3, DNA repair helicase, DNA repair protein complementing XP-B cells, TFIIH 89 kDa subunit, TFIIH basal transcription factor complex 89 kDa subunit, TFIIH basal transcription factor complex helicase XPB subunit, TFIIH p89, TFIIH subunit XPB, basic transcription factor 2 89 kDa subunit, excision repair cross-complementation group 3, excision repair cross-complementing rodent repair deficiency, complementation group 3, xeroderma pigmentosum group B-complementing protein, xeroderma pigmentosum, complementation group B,)
• NCBI Gene ID: 2071
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P19447
  UNIPROT ID#>>G3V1S1
  UNIPROT ID#>>B3KRG2
  UNIPROT ID#>>B3KTH1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ERCC excision repair 3, TFIIH core complex helicase subunit interacts with:

• activating transcription factor 7 interacting protein
  ADAMTS like 4
  basic leucine zipper nuclear factor 1
  centrosomal protein 70
  centrosomal protein 76
  COP9 signalosome subunit 2
  egl-9 family hypoxia inducible factor 3
  ERCC excision repair 5, endonuclease
  ERCC excision repair 6, chromatin remodeling factor
  fibrinogen like 1
  G1 to S phase transition 1
  GCN1 activator of EIF2AK4
  general transcription factor IIE subunit 1
  general transcription factor IIE subunit 2
  general transcription factor IIH subunit 1
  general transcription factor IIH subunit 2
  general transcription factor IIH subunit 3
  general transcription factor IIH subunit 4
  general transcription factor IIH subunit 5
  golgin A2
  GTF2H2 family member C
  GTF2H2 family member C, copy 2
  interferon regulatory factor 1
  karyopherin subunit alpha 3
  KRAS proto-oncogene, GTPase
  leucine rich repeat containing 41
  leucine zipper tumor suppressor 2
  MAGE family member D1
  MCF.2 cell line derived transforming sequence
  mediator complex subunit 4
  MMS19 homolog, cytosolic iron-sulfur assembly component
  MNAT1 component of CDK activating kinase
  Myb/SANT DNA binding domain containing 2
  MYC proto-oncogene, bHLH transcription factor
  NOP2/Sun RNA methyltransferase 2
  nuclear factor of activated T cells 2
  nuclear RNA export factor 1
  peptidylprolyl isomerase E
  pleckstrin homology domain containing A4
  poly(rC) binding protein 1
  proteasome 26S subunit, ATPase 5
  RAD52 homolog, DNA repair protein
  rhophilin associated tail protein 1
  ribosomal protein L35
  ribosome binding protein 1
  RNA polymerase II subunit A
  RNA polymerase II subunit C
  signal recognition particle 72
  SIX homeobox 5
  SNW domain containing 1
  spectrin alpha, erythrocytic 1
  SRSF protein kinase 2
  TATA-box binding protein associated factor 7
  tripartite motif containing 14
  tripartite motif containing 25
  tripartite motif containing 27
  tumor protein p53
  tumor protein p53 binding protein 1
  ubiquitin specific peptidase 7
  UBX domain protein 7
  UV stimulated scaffold protein A
  XPC complex subunit, DNA damage recognition and repair factor
  zinc finger and BTB domain containing 10
  zinc finger and SCAN domain containing 1
  zinc finger protein 143

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.