POLR2C, RNA polymerase II subunit C

POLR2C, RNA polymerase II subunit C

• This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II 33 kDa polypeptide, DNA-directed RNA polymerase II subunit C, RNA polymerase II subunit 3, RNA polymerase II subunit B3, RPB33, polymerase (RNA) II (DNA directed) polypeptide C, 33kDa, polymerase (RNA) II subunit C, RPB3, RPB31, hRPB33, hsRPB3,)
• NCBI Gene ID: 5432
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6FGR6
  UNIPROT ID#>>P19387
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RNA polymerase II subunit C interacts with:

• activating transcription factor 7 interacting protein
  activating transcription factor 7 interacting protein
  autophagy related 16 like 1
  bromodomain adjacent to zinc finger domain 1B
  centriolin
  chromosome 11 open reading frame 58
  coiled-coil alpha-helical rod protein 1
  COP9 signalosome subunit 5
  CTD phosphatase subunit 1
  CTR9 homolog, Paf1/RNA polymerase II complex component
  cullin 3
  cullin 5
  developmental pluripotency-associated 3
  double PHD fingers 2
  egl-9 family hypoxia inducible factor 3
  EH domain binding protein 1 like 1
  elongation factor Tu GTP binding domain containing 2
  elongin A
  ergosterol biosynthesis 28 homolog
  exportin 1
  general transcription factor IIB
  GPN-loop GTPase 3
  H2A clustered histone 20
  H4 clustered histone 1
  heterogeneous nuclear ribonucleoprotein R
  integrator complex subunit 10
  integrator complex subunit 12
  integrator complex subunit 3
  integrator complex subunit 5
  integrator complex subunit 6
  itchy E3 ubiquitin protein ligase
  LEO1 homolog, Paf1/RNA polymerase II complex component
  ligand dependent nuclear receptor interacting factor 1
  mediator complex subunit 10
  mediator complex subunit 17
  mediator complex subunit 19
  mediator complex subunit 26
  mediator complex subunit 27
  mediator complex subunit 28
  mediator complex subunit 29
  mediator complex subunit 9
  mediator of DNA damage checkpoint 1
  metastasis associated 1 family member 2
  mitogen-activated protein kinase 6
  negative elongation factor complex member A
  negative elongation factor complex member B
  negative elongation factor complex member C/D
  negative elongation factor complex member E
  N-terminal EF-hand calcium binding protein 2
  nudix hydrolase 21
  OTU deubiquitinase 5
  PHD finger protein 8
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  proteasome 20S subunit beta 9
  protein arginine methyltransferase 5
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 4 regulatory subunit 1
  Rac GTPase-activating protein 1
  RecQ like helicase 4
  RecQ like helicase 5
  regulation of nuclear pre-mRNA domain containing 1B
  regulation of nuclear pre-mRNA domain containing 1B
  ribosomal protein S9
  RNA guanylyltransferase and 5'-phosphatase
  RNA polymerase I and III subunit C
  RNA polymerase I and III subunit D
  RNA polymerase II associated protein 1
  RNA polymerase II associated protein 2
  RNA polymerase II subunit C
  RNA polymerase II subunit D
  RNA polymerase II subunit G
  RNA polymerase II subunit I
  RNA polymerase II subunit J
  RNA polymerase II subunit M
  RNA polymerase II, I and III subunit E
  RNA polymerase II, I and III subunit F
  RNA polymerase II, I and III subunit H
  RNA polymerase II, I and III subunit K
  RNA polymerase II, I and III subunit L
  RNA polymerase III subunit G
  SPT5 homolog, DSIF elongation factor subunit
  SPT6 homolog, histone chaperone and transcription elongation factor
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRY-box transcription factor 2
  stanniocalcin 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  TATA-box binding protein associated factor 15
  TNFAIP3 interacting protein 2
  transcription elongation factor A1
  transcriptional adaptor 2A
  tumor protein p63
  ubiquitin C
  ubiquitin conjugating enzyme E2 W
  WD repeat domain 77
  WD repeat domain 92
  Wnt family member 1
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  zinc finger protein 326

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.