HBB, hemoglobin subunit beta

HBB, hemoglobin subunit beta

• The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

• Gene Synonyms (hemoglobin subunit beta, beta globin chain, hemoglobin beta subunit, hemoglobin, beta, CD113t-C, ECYT6, beta-globin,)
• NCBI Gene ID: 3043
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P68871
  UNIPROT ID#>>D9YZU5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hemoglobin subunit beta interacts with:

• alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
  anterior gradient 2, protein disulphide isomerase family member
  APC down-regulated 1
  centrosomal protein 250
  COP9 signalosome subunit 3
  cytohesin 1 interacting protein
  dehydrogenase/reductase 2
  double PHD fingers 2
  eukaryotic translation initiation factor 4A3
  family with sequence similarity 189 member B
  family with sequence similarity 234 member B
  FERM domain containing 1
  ganglioside induced differentiation associated protein 1
  glycerophosphodiester phosphodiesterase domain containing 1
  H2B clustered histone 11
  haptoglobin
  heat shock protein family A (Hsp70) member 8
  hemoglobin subunit beta
  hemoglobin subunit gamma 2
  hemoglobin subunit theta 1
  hemoglobin subunit zeta
  Josephin domain containing 2
  lysophosphatidic acid receptor 2
  MDM4 regulator of p53
  mediator complex subunit 4
  minichromosome maintenance complex component 2
  mitogen-activated protein kinase 6
  MSL complex subunit 2
  NADH:ubiquinone oxidoreductase complex assembly factor 5
  nuclear receptor subfamily 2 group C member 2
  origin recognition complex subunit 2
  patatin like phospholipase domain containing 1
  PDZ and LIM domain 7
  phosphatase and tensin homolog
  plexin B1
  poly(A) binding protein cytoplasmic 1
  poly(A) specific ribonuclease subunit PAN2
  polynucleotide kinase 3'-phosphatase
  proteasome 26S subunit, ATPase 5
  pyroglutamyl-peptidase I
  RNA binding motif protein 8A
  RNA polymerase II subunit A
  selenoprotein T
  semenogelin 2
  SMG6 nonsense mediated mRNA decay factor
  SMG7 nonsense mediated mRNA decay factor
  solute carrier family 2 member 14
  SUMO specific peptidase 2
  transmembrane protein 92
  tumor protein p53
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  UPF1 RNA helicase and ATPase
  UPF2 regulator of nonsense mediated mRNA decay
  UPF3A regulator of nonsense mediated mRNA decay
  UPF3B regulator of nonsense mediated mRNA decay
  X-ray repair cross complementing 5
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.