HSPA1B, heat shock protein family A (Hsp70) member 1B

HSPA1B, heat shock protein family A (Hsp70) member 1B

• This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

• Gene Synonyms (heat shock 70 kDa protein 1B, HSP70-1/HSP70-2, HSP70.1/HSP70.2, Heat shock 70 kDa protein 1, Heat shock 70 kDa protein 1A, heat shock 70 kDa protein 1/2, heat shock 70 kDa protein 1A/1B, heat shock 70 kDa protein 2, heat shock 70kD protein 1B, heat shock 70kDa protein 1B, HSP70-1, HSP70-1B, HSP70-2, HSP70.1, HSP70.2, HSP72, HSPA1, HSX70,)
• NCBI Gene ID: 3304
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K5I0
  UNIPROT ID#>>P0DMV8
  UNIPROT ID#>>P0DMV9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heat shock protein family A (Hsp70) member 1B interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  apoptosis inducing factor mitochondria associated 1
  ariadne RBR E3 ubiquitin protein ligase 2
  ASH2 like, histone lysine methyltransferase complex subunit
  BAF nuclear assembly factor 1
  BAG cochaperone 4
  centriolin
  centrosomal protein 170
  contactin associated protein 1
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  cullin 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  cullin associated and neddylation dissociated 1
  cyclin I family member 2
  defective in cullin neddylation 1 domain containing 1
  DENN domain containing 2D
  derlin 1
  dual specificity tyrosine phosphorylation regulated kinase 2
  dynamin binding protein
  Fas associated factor 1
  F-box protein 6
  folliculin
  folliculin interacting protein 1
  folliculin interacting protein 2
  H4 clustered histone 1
  heat shock protein 90 alpha family class A member 1
  histone deacetylase 6
  HSPA (Hsp70) binding protein 1
  inositol polyphosphate phosphatase like 1
  integrin subunit alpha 4
  kelch like family member 34
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat containing 28
  leucine rich repeat kinase 2
  MAGE family member A3
  matrin 3
  NEDD8 ubiquitin like modifier
  nephrocystin 4
  NIMA related kinase 8
  ninein like
  nuclear transcription factor, X-box binding 1
  palmitoyl-protein thioesterase 1
  peroxisome proliferator activated receptor gamma
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  phosphoinositide-3-kinase regulatory subunit 2
  prohibitin
  proliferation-associated 2G4
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, non-ATPase 14
  protein arginine methyltransferase 8
  protein phosphatase 5 catalytic subunit
  PTEN induced kinase 1
  RAD18 E3 ubiquitin protein ligase
  RB binding protein 5, histone lysine methyltransferase complex subunit
  ring finger protein 2
  ring finger protein 31
  RIO kinase 1
  SET domain containing 1A, histone lysine methyltransferase
  SHC adaptor protein 1
  SMAD specific E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 4
  solute carrier family 27 member 3
  staufen double-stranded RNA binding protein 1
  STIP1 homology and U-box containing protein 1
  stress induced phosphoprotein 1
  SUMO specific peptidase 2
  thioredoxin interacting protein
  transcription elongation regulator 1
  transglutaminase 2
  tripartite motif containing 25
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquilin 2
  ubiquitin associated and SH3 domain containing B
  ubiquitin like 4A
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.