MXD1, MAX dimerization protein 1

MXD1, MAX dimerization protein 1

• This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

• Gene Synonyms (BHLHC58, MAD, MAD1, max dimerization protein 1, MAX-binding protein, antagonizer of myc transcriptional activity, max dimerizer 1,)
• NCBI Gene ID: 4084
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q05195
  UNIPROT ID#>>B7ZLI7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MAX dimerization protein 1 interacts with:

• AT-rich interaction domain 4A
  AT-rich interaction domain 4B
  BRMS1 like transcriptional repressor
  BRMS1 transcriptional repressor and anoikis regulator
  chromobox 3
  DISC1 scaffold protein
  L3MBTL histone methyl-lysine binding protein 2
  lysine demethylase 5A
  MAX dimerization protein 1
  MAX dimerization protein 3
  MAX dimerization protein 4
  MAX dimerization protein MGA
  MAX dimerization protein MLX
  MAX network transcriptional repressor
  MYC associated factor X
  MYC proto-oncogene, bHLH transcription factor
  MYCL proto-oncogene, bHLH transcription factor
  MYCN proto-oncogene, bHLH transcription factor
  phosphatase and tensin homolog
  PML nuclear body scaffold
  PML-RARA regulated adaptor molecule 1
  polycomb group ring finger 6
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase B1
  ring finger protein 1
  ring finger protein 2
  RING1 and YY1 binding protein
  SAP30 like
  SDS3 homolog, SIN3A corepressor complex component
  SIN3 transcription regulator family member A
  SIN3 transcription regulator family member B
  Sin3A associated protein 130
  Sin3A associated protein 30
  structural maintenance of chromosomes 3
  transcription factor Dp-1
  transcriptional regulator, SIN3A (yeast)
  transcriptional regulator, SIN3B (yeast)
  vitamin D receptor
  YY1 associated factor 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.