MAT1A, methionine adenosyltransferase 1A

MAT1A, methionine adenosyltransferase 1A

• This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]

• Gene Synonyms (MAT, MATA1, SAMS, SAMS1, S-adenosylmethionine synthase isoform type-1, MAT 1, MAT-I/III, S-adenosylmethionine synthetase isoform type-1, adoMet synthase 1, adoMet synthetase 1, methionine adenosyltransferase 1, methionine adenosyltransferase I, alpha, methionine adenosyltransferase I/III,)
• NCBI Gene ID: 4143
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q00266
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

methionine adenosyltransferase 1A interacts with:

• ASPSCR1 tether for SLC2A4, UBX domain containing
  exportin 1
  IST1 factor associated with ESCRT-III
  methionine adenosyltransferase 1A
  methionine adenosyltransferase 2A
  methionine adenosyltransferase 2B
  mevalonate kinase
  pleckstrin homology domain containing A4
  RAB interacting factor
  ribulose-5-phosphate-3-epimerase
  SHC adaptor protein 1
  ubiquitin conjugating enzyme E2 A
  VPS26 endosomal protein sorting factor C

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.