PDE6G, phosphodiesterase 6G

PDE6G, phosphodiesterase 6G

• This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

• Gene Synonyms (retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, GMP-PDE gamma, phosphodiesterase 6G, cGMP-specific, rod, gamma, rod cG-PDE G, PDEG, RP57,)
• NCBI Gene ID: 5148
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P18545
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphodiesterase 6G interacts with:

• basic helix-loop-helix family member e40
  formin binding protein 1
  L3MBTL histone methyl-lysine binding protein 3
  mitogen-activated protein kinase 3
  phosphodiesterase 6G
  protein kinase AMP-activated non-catalytic subunit beta 2
  SRC proto-oncogene, non-receptor tyrosine kinase
  thyroid hormone receptor interactor 10

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.