MTOR, mechanistic target of rapamycin kinase

MTOR, mechanistic target of rapamycin kinase

• The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]

• Gene Synonyms (FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, serine/threonine-protein kinase mTOR, FK506 binding protein 12-rapamycin associated protein 2, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP-rapamycin associated protein, FKBP12-rapamycin complex-associated protein 1, mammalian target of rapamycin, mechanistic target of rapamycin (serine/threonine kinase), rapamycin and FKBP12 target 1, rapamycin associated protein FRAP2, rapamycin target protein 1,)
• NCBI Gene ID: 2475
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P42345
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mechanistic target of rapamycin kinase interacts with:

• 3-phosphoinositide dependent protein kinase 1
  5-hydroxytryptamine receptor 6
  5'-nucleotidase ecto
  AKT1 substrate 1
  assembly factor for spindle microtubules
  autophagy and beclin 1 regulator 1
  BAG cochaperone 6
  beclin 1
  BICD cargo adaptor 2
  BRCA1 associated ATM activator 1
  CAP-Gly domain containing linker protein 1
  carbonic anhydrase 14
  CD244 molecule
  CD274 molecule
  CD83 molecule
  cell division cycle 37, HSP90 cochaperone
  chromosome 7 open reading frame 25
  complement factor properdin
  cytidine monophosphate N-acetylneuraminic acid synthetase
  cytoskeleton associated protein 5
  decapping mRNA 2
  DEP domain containing MTOR interacting protein
  distal membrane arm assembly complex 1
  DNA topoisomerase I
  eukaryotic translation initiation factor 3 subunit B
  eukaryotic translation initiation factor 3 subunit C
  eukaryotic translation initiation factor 3 subunit D
  eukaryotic translation initiation factor 3 subunit F
  exportin 1
  exportin 4
  exportin 6
  F-box and WD repeat domain containing 7
  F-box protein 8
  FKBP prolyl isomerase 8
  G protein subunit beta 1
  G protein subunit beta 2
  G protein subunit beta 3
  G protein subunit beta 5
  G protein subunit gamma 2
  general transcription factor IIIC subunit 1
  gephyrin
  glycogen synthase kinase 3 beta
  growth factor independent 1B transcriptional repressor
  heat shock protein family A (Hsp70) member 4
  heterogeneous nuclear ribonucleoprotein D
  HRas proto-oncogene, GTPase
  huntingtin
  hypoxia inducible factor 1 subunit alpha
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inhibitor of nuclear factor kappa B kinase subunit beta
  insulin like growth factor 1 receptor
  insulin receptor substrate 1
  insulin receptor substrate 2
  integrin beta 1 (fibronectin receptor beta)
  integrin linked kinase
  jun B proto-oncogene
  kinesin family member 19A
  KRAS proto-oncogene, GTPase
  La ribonucleoprotein 1, translational regulator
  LanC like 2
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
  LDL receptor related protein associated protein 1
  left-right determination factor 1
  leucyl-tRNA synthetase 1
  limb development membrane protein 1 like
  LLGL scribble cell polarity complex component 2
  LY6/PLAUR domain containing 3
  lysine demethylase 5C
  lysosomal associated membrane protein 1
  lysosomal associated membrane protein 2
  MAF1 homolog, negative regulator of RNA polymerase III
  MAPK associated protein 1
  MDM4 regulator of p53
  mechanistic target of rapamycin kinase
  metastasis associated 1 family member 2
  methionyl aminopeptidase 2
  mitochondrial ribosomal protein L13
  mitochondrial ribosomal protein L19
  mitochondrial ribosomal protein S5
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase kinase 1
  mitogen-activated protein kinase kinase kinase 12
  mitogen-activated protein kinase kinase kinase 3
  MLX interacting protein
  MLX interacting protein like
  Mov10 RISC complex RNA helicase
  MTOR associated protein, LST8 homolog
  MYC associated factor X
  myotubularin related protein 3
  NADH:ubiquinone oxidoreductase subunit A8
  NADH:ubiquinone oxidoreductase subunit A9
  NADH:ubiquinone oxidoreductase subunit B2
  neuropeptide Y receptor Y2
  neurotrophic receptor tyrosine kinase 3
  NFKB inhibitor alpha
  nibrin
  NRAS proto-oncogene, GTPase
  nuclear assembly factor 1 ribonucleoprotein
  nuclear cap binding protein subunit 1
  nuclear RNA export factor 1
  parkin RBR E3 ubiquitin protein ligase
  phosphatase and tensin homolog
  phosphatase, orphan 1
  phosphatidylinositol 3-kinase catalytic subunit type 3
  phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
  phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
  phosphoinositide-3-kinase regulatory subunit 4
  phospholipase D2
  platelet derived growth factor receptor alpha
  pleckstrin homology domain containing A4
  PML nuclear body scaffold
  progesterone receptor membrane component 1
  proliferation-associated 2G4
  proline rich 5
  proline rich 5 like
  protein disulfide isomerase family A member 3
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase C alpha
  protein kinase C delta
  protein kinase cAMP-dependent type I regulatory subunit alpha
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 2 regulatory subunit Balpha
  proton activated chloride channel 1
  pyrimidinergic receptor P2Y6
  pyruvate dehydrogenase kinase 1
  Rab geranylgeranyltransferase subunit beta
  RAB1A, member RAS oncogene family
  RAP1A, member of RAS oncogene family
  RAP2A, member of RAS oncogene family
  Ras homolog enriched in brain
  Ras homolog, mTORC1 binding
  Ras related GTP binding B
  Ras related GTP binding C
  Ras related GTP binding D
  regulatory associated protein of MTOR complex 1
  regulatory associated protein of MTOR, complex 1
  RHEB like 1
  ribosomal protein L23
  ribosomal protein L23a
  ribosomal protein L26
  ribosomal protein L5
  ribosomal protein S6
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase B1
  ribosomal protein S6 kinase B2
  ribosomal protein S6 kinase, polypeptide 1
  RP2 activator of ARL3 GTPase
  RPTOR independent companion of MTOR complex 2
  rubicon autophagy regulator
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  septin 2
  sequestosome 1
  serine hydroxymethyltransferase 2
  serine/threonine kinase 38
  serum/glucocorticoid regulated kinase 1
  serum/glucocorticoid regulated kinase 1
  SHOC2 leucine rich repeat scaffold protein
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  single-pass membrane protein with aspartate rich tail 1
  sirtuin 1
  sirtuin 7
  SMAD family member 4
  small glutamine rich tetratricopeptide repeat containing beta
  small nuclear RNA activating complex polypeptide 1
  small RNA binding exonuclease protection factor La
  small ubiquitin like modifier 1
  sodium voltage-gated channel beta subunit 2
  sodium voltage-gated channel beta subunit 3
  S-phase kinase associated protein 2
  staufen double-stranded RNA binding protein 1
  SUZ12 polycomb repressive complex 2 subunit
  synaptotagmin binding cytoplasmic RNA interacting protein
  TANK binding kinase 1
  TELO2 interacting protein 1
  telomerase reverse transcriptase
  telomere maintenance 2
  telomeric repeat binding factor 1
  THADA armadillo repeat containing
  TNF alpha induced protein 3
  TNF receptor associated factor 2
  TNF receptor associated factor 6
  TNF superfamily member 13b
  tripartite motif containing 25
  tripartite motif containing 28
  tripartite motif containing 37
  tRNA methyltransferase 61A
  tubulin alpha 1a
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquilin 1
  ubiquitin specific peptidase 9 X-linked
  unc-51 like autophagy activating kinase 1
  unc-93 homolog B1, TLR signaling regulator
  UV radiation resistance associated
  valosin containing protein
  vasoactive intestinal peptide receptor 2
  vir like m6A methyltransferase associated
  VPS16 core subunit of CORVET and HOPS complexes
  V-set and immunoglobulin domain containing 2
  WD repeat domain, phosphoinositide interacting 2
  WEE1 G2 checkpoint kinase
  WW domain containing oxidoreductase
  YEATS domain containing 4
  zinc and ring finger 2
  zinc finger and SCAN domain containing 26
  zinc finger containing ubiquitin peptidase 1
  zinc finger DHHC-type palmitoyltransferase 18
  zinc finger DHHC-type palmitoyltransferase 23

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.