HMGA1, high mobility group AT-hook 1

HMGA1, high mobility group AT-hook 1

• This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]

• Gene Synonyms (high mobility group protein HMG-I/HMG-Y, high mobility group protein A1, high mobility group protein R, high-mobility group (nonhistone chromosomal) protein isoforms I and Y, nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y, HMG-R, HMGA1A, HMGIY,)
• NCBI Gene ID: 3159
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5T6U8
  UNIPROT ID#>>P17096
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

high mobility group AT-hook 1 interacts with:

• adaptor related protein complex 4 subunit mu 1
  agrin
  anterior gradient 2, protein disulphide isomerase family member
  autophagy related 16 like 1
  BAF nuclear assembly factor 1
  cap methyltransferase 1
  cell division cycle 14B
  chromobox 7
  c-src tyrosine kinase
  cullin 7
  CWC27 spliceosome associated cyclophilin
  decapping enzyme, scavenger
  developmental pluripotency associated 4
  DnaJ heat shock protein family (Hsp40) member C8
  elongation factor Tu GTP binding domain containing 2
  ER membrane protein complex subunit 2
  eukaryotic translation initiation factor 2 subunit beta
  fibrillarin
  forkhead box A1
  G1 to S phase transition 1
  G3BP stress granule assembly factor 1
  H3 clustered histone 1
  H4 clustered histone 1
  heat shock protein 90 alpha family class A member 1
  heat shock protein family A (Hsp70) member 1A
  hemogen
  heterogeneous nuclear ribonucleoprotein A/B
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein L
  histone PARylation factor 1
  homeodomain interacting protein kinase 2
  insulin receptor
  integrin subunit beta 7
  interferon regulatory factor 1
  Jun proto-oncogene, AP-1 transcription factor subunit
  kinesin family member C1
  lysine acetyltransferase 2B
  methionyl aminopeptidase 2
  MYC proto-oncogene, bHLH transcription factor
  Nanog homeobox
  NK2 homeobox 1
  nuclear factor kappa B subunit 1
  nuclear factor of activated T cells 1
  nuclear receptor corepressor 2
  nuclear transcription factor Y subunit alpha
  nucleolin
  nucleophosmin 1
  Obg like ATPase 1
  obscurin like cytoskeletal adaptor 1
  origin recognition complex subunit 2
  origin recognition complex subunit 6
  oxytocin/neurophysin I prepropeptide
  PC4 and SFRS1 interacting protein 1
  peroxisome proliferator activated receptor gamma
  poly(A) specific ribonuclease subunit PAN2
  poly(rC) binding protein 1
  poly(rC) binding protein 2
  polycomb group ring finger 1
  polypyrimidine tract binding protein 1
  potassium voltage-gated channel subfamily Q member 4
  POU class 2 homeobox 1
  POU class 2 homeobox 2
  POU class 3 homeobox 1
  POU class 5 homeobox 1
  PR/SET domain 16
  proliferation-associated 2G4
  protein arginine methyltransferase 6
  protein kinase C alpha
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 regulatory subunit 8
  Rac GTPase activating protein 1
  RE1 silencing transcription factor
  retinoic acid receptor alpha
  retinoic acid receptor gamma
  retinoid X receptor alpha
  ring finger protein 123
  ring finger protein 4
  ring-box 1
  serum response factor
  signal recognition particle 72
  small RNA binding exonuclease protection factor La
  Sp1 transcription factor
  SRSF protein kinase 2
  stromal antigen 2
  SUFU negative regulator of hedgehog signaling
  synaptotagmin binding cytoplasmic RNA interacting protein
  telomeric repeat binding factor 2
  tripartite motif containing 29
  tumor protein p53
  tyrosine kinase 2
  ubiquitin conjugating enzyme E2 I
  UPF2 regulator of nonsense mediated mRNA decay
  VRK serine/threonine kinase 1
  zinc finger and SCAN domain containing 5A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.