DPH1, diphthamide biosynthesis 1

DPH1, diphthamide biosynthesis 1

• The protein encoded by this gene is an enzyme involved in the biosynthesis of diphthamide, a modified histidine found only in elongation factor-2 (EEF2). Diphthamide residues in EEF2 are targeted for ADP-ribosylation by diphtheria toxin and Pseudomonas exotoxin A. Defects in this gene have been associated with both ovarian cancer and autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies. [provided by RefSeq, Oct 2016]

• Gene Synonyms (DEDSSH, DPH2L, DPH2L1, OVCA1, 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1, DPH-like 1, DPH1 homolog, DPH2-like 1, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1, candidate tumor suppressor in ovarian cancer 1, diphthamide biosynthesis protein 1, diphthamide biosynthesis protein 2 homolog-like 1, diphtheria toxin resistance protein 1, diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1, ovarian cancer-associated gene 1 protein, ovarian tumor suppressor candidate 1,)
• NCBI Gene ID: 1801
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BZG8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

diphthamide biosynthesis 1 interacts with:

• arylsulfatase G
  caspase recruitment domain family member 8
  DDB1 and CUL4 associated factor 13
  diphthamide biosynthesis 2
  ephrin B2
  eukaryotic translation elongation factor 2
  glucose-fructose oxidoreductase domain containing 1
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  inosine monophosphate dehydrogenase 1
  kaptin, actin binding protein
  MMS19 homolog, cytosolic iron-sulfur assembly component
  Mov10 RISC complex RNA helicase
  MYCL proto-oncogene, bHLH transcription factor
  nuclear RNA export factor 1
  phospholipid scramblase 4
  pre-mRNA processing factor 4
  purinergic receptor P2X 5
  RAB30, member RAS oncogene family
  regulator of G protein signaling 20
  RNA binding motif protein 8A
  serine peptidase inhibitor, Kunitz type 2
  sulfotransferase family 4A member 1
  TNF receptor superfamily member 1A
  transcription factor CP2
  tropomyosin 4
  TUB like protein 3
  tumor protein p53
  tumor protein p63
  tumor protein p73
  ubiquitin C
  WD repeat domain, phosphoinositide interacting 2
  zinc ribbon domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.