GSTP1, glutathione S-transferase pi 1

GSTP1, glutathione S-transferase pi 1

• Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

• Gene Synonyms (glutathione S-transferase P, GST class-pi, GSTP1-1, deafness, X-linked 7, epididymis secretory protein Li 22, fatty acid ethyl ester synthase III, DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI,)
• NCBI Gene ID: 2950
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P09211
  UNIPROT ID#>>V9HWE9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glutathione S-transferase pi 1 interacts with:

• ADAMTS like 4
  aldehyde dehydrogenase 4 family member A1
  amyloid beta precursor protein binding protein 2
  caspase recruitment domain family member 10
  chloride intracellular channel 4
  COP9 signalosome subunit 5
  cullin 2
  cullin 3
  cullin 7
  cysteine rich tail 1
  cytidine/uridine monophosphate kinase 1
  cytochrome c oxidase subunit 5A
  DDB1 and CUL4 associated factor 4 like 2
  DNA ligase 4
  DNA polymerase delta interacting protein 2
  ETHE1 persulfide dioxygenase
  F-box and leucine rich repeat protein 12
  ferredoxin 2
  four and a half LIM domains 5
  galectin 3
  glutamine amidotransferase like class 1 domain containing 3A
  glutaredoxin 5
  glutathione S-transferase omega 1
  glutathione S-transferase pi 1
  glutathione S-transferase theta 2 (gene/pseudogene)
  glutathione S-transferase theta 2B
  glyoxylate and hydroxypyruvate reductase
  H4 histone 16
  heat shock protein 90 alpha family class A member 1
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein K
  HEXIM P-TEFb complex subunit 1
  histidine triad nucleotide binding protein 2
  homeobox A1
  inorganic pyrophosphatase 1
  inorganic pyrophosphatase 2
  integrin subunit alpha 4
  ISG15 ubiquitin like modifier
  isocitrate dehydrogenase (NADP(+)) 2
  keratin 31
  keratin 33B
  keratin 34
  keratin 83
  keratin associated protein 10-3
  keratin associated protein 10-7
  keratin associated protein 10-9
  keratin associated protein 1-1
  keratin associated protein 1-3
  keratin associated protein 3-1
  keratin associated protein 3-3
  keratin associated protein 6-2
  La ribonucleoprotein 7, transcriptional regulator
  lactamase beta 2
  leucine aminopeptidase 3
  leucine rich repeat kinase 2
  LRP2 binding protein
  lysine demethylase 6B
  mercaptopyruvate sulfurtransferase
  microtubule associated scaffold protein 2
  minichromosome maintenance complex component 2
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase kinase kinase 1
  multiple inositol-polyphosphate phosphatase 1
  mutL homolog 1
  MYC proto-oncogene, bHLH transcription factor
  myotrophin
  NADH:ubiquinone oxidoreductase subunit AB1
  NBPF member 19
  neudesin neurotrophic factor
  neurotrophic receptor tyrosine kinase 1
  NHL repeat containing 2
  notch 2 N-terminal like A
  palmitoyl-protein thioesterase 1
  parkin RBR E3 ubiquitin protein ligase
  Parkinsonism associated deglycase
  partner of NOB1 homolog
  peptidase, mitochondrial processing subunit alpha
  peroxiredoxin 2
  peroxiredoxin 6
  phosphoglucomutase 1
  pleiotrophin
  protein O-glucosyltransferase 3
  regulatory associated protein of MTOR complex 1
  RNA binding motif protein X-linked
  sepiapterin reductase
  sirtuin 7
  small ubiquitin like modifier 4
  SR-related CTD associated factor 1
  superoxide dismutase 1
  thioredoxin
  thioredoxin like 1
  thioredoxin like 4A
  TNF receptor associated factor 2
  transglutaminase 1
  transglutaminase 2
  transketolase
  triosephosphate isomerase 1
  tubulin folding cofactor A
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin C
  ubiquitin conjugating enzyme E2 A
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 O
  ubiquitin C-terminal hydrolase L1
  vascular cell adhesion molecule 1
  vesicle associated membrane protein 5
  vir like m6A methyltransferase associated
  zinc finger protein 518A
  zinc finger protein 655

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.