IL16, interleukin 16

IL16, interleukin 16

• The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

• Gene Synonyms (pro-interleukin-16, lymphocyte chemoattractant factor, neuronal interleukin 16, prointerleukin 16, LCF, NIL16, PRIL16, prIL-16,)
• NCBI Gene ID: 3603
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UME6
  UNIPROT ID#>>Q14005
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 16 interacts with:

• basic leucine zipper nuclear factor 1
  bolA family member 2
  bolA family member 2B
  calcium binding and coiled-coil domain 2
  calcium/calmodulin dependent protein kinase I
  caspase recruitment domain family member 10
  centrosomal protein 72
  coiled-coil domain containing 184
  coiled-coil domain containing 33
  cysteine rich tail 1
  DMRT like family B with proline rich C-terminal 1
  EGF containing fibulin extracellular matrix protein 2
  family with sequence similarity 124 member A
  F-box and leucine rich repeat protein 13
  four and a half LIM domains 5
  FTO alpha-ketoglutarate dependent dioxygenase
  galectin 14
  golgin A6 family like 9
  heat shock transcription factor 2 binding protein
  histone deacetylase 3
  homeobox and leucine zipper encoding
  hook microtubule tethering protein 2
  interleukin 16
  janus kinase and microtubule interacting protein 1
  keratin 31
  keratin 86
  keratin associated protein 10-8
  keratin associated protein 1-1
  keratin associated protein 1-3
  keratin associated protein 3-1
  kinesin family member 16B
  kinesin family member C3
  KN motif and ankyrin repeat domains 2
  L3MBTL histone methyl-lysine binding protein 3
  ligand of numb-protein X 1
  ligand of numb-protein X 2
  LIM domain only 3
  lysine demethylase 1A
  methyl-CpG binding domain protein 3 like 1
  microtubule associated scaffold protein 2
  midline 2
  MIER family member 2
  myogenin
  NADPH oxidase activator 1
  neuropeptide B
  N-terminal glutamine amidase 1
  nuclear receptor binding protein 2
  Opa interacting protein 5
  PDZ and LIM domain 7
  potassium channel tetramerization domain containing 9
  potassium inwardly rectifying channel subfamily J member 10
  potassium inwardly rectifying channel subfamily J member 15
  potassium inwardly rectifying channel subfamily J member 2
  potassium inwardly rectifying channel subfamily J member 4
  potassium voltage-gated channel subfamily A member 3
  potassium voltage-gated channel subfamily D member 1
  potassium voltage-gated channel subfamily D member 2
  PR/SET domain 6
  prefoldin subunit 5
  proline rich 13
  proline-serine-threonine phosphatase interacting protein 1
  protein interacting with PRKCA 1
  protein phosphatase 1 regulatory subunit 12A
  protein phosphatase 1 regulatory subunit 12B
  protein phosphatase 1 regulatory subunit 12C
  protein phosphatase 1 regulatory subunit 16A
  RANBP2-type and C3HC4-type zinc finger containing 1
  Rap guanine nucleotide exchange factor 2
  ring finger protein 144B
  ring finger protein 169
  SERTA domain containing 3
  spermatogenesis and oogenesis specific basic helix-loop-helix 1
  sprouty related EVH1 domain containing 1
  suppressor of variegation 3-9 homolog 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  TEPSIN adaptor related protein complex 4 accessory protein
  thyroid hormone receptor interactor 6
  tribbles pseudokinase 3
  tripartite motif containing 27
  tripartite motif containing 42
  tuftelin interacting protein 11
  UBX domain protein 11
  USH1 protein network component harmonin binding protein 1
  vir like m6A methyltransferase associated
  WW domain containing transcription regulator 1
  zinc finger and BTB domain containing 39
  zinc finger imprinted 2
  zinc finger protein 143
  zinc finger protein 148
  zinc finger protein 165
  zinc finger protein 474
  zinc finger protein 526
  zinc finger protein 572
  zinc finger protein 581
  zinc finger protein 620
  zinc finger protein 774
  zinc finger protein 777
  zinc finger protein 835
  zinc finger RANBP2-type containing 1
  zinc ribbon domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.