VPS52, VPS52 subunit of GARP complex

VPS52, VPS52 subunit of GARP complex

• This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

• Gene Synonyms (vacuolar protein sorting-associated protein 52 homolog, SAC2 suppressor of actin mutations 2-like protein, VPS52, GARP complex subunit, vacuolar protein sorting 52 homolog, ARE1, SAC2, SACM2L, dJ1033B10.5,)
• NCBI Gene ID: 6293
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KMF7
  UNIPROT ID#>>Q4VXZ2
  UNIPROT ID#>>A0A1U9X8S4
  UNIPROT ID#>>Q8N1B4
  UNIPROT ID#>>B4DS44
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

VPS52 subunit of GARP complex interacts with:

• aryl hydrocarbon receptor nuclear translocator 2
  ATPase H+ transporting V1 subunit D
  BLOC-1 related complex subunit 6
  C2 calcium dependent domain containing 6
  calcium binding protein 5
  cell division cycle 20B
  centrosomal protein 19
  chromosome 1 open reading frame 109
  chromosome 1 open reading frame 216
  cilia and flagella associated protein 206
  coiled-coil alpha-helical rod protein 1
  coiled-coil domain containing 102B
  coiled-coil domain containing 13
  coiled-coil domain containing 146
  coiled-coil domain containing 185
  coiled-coil domain containing 187
  coiled-coil domain containing 33
  coiled-coil domain containing 57
  CTD phosphatase subunit 1
  CWF19 like cell cycle control factor 2
  DnaJ heat shock protein family (Hsp40) member C11
  EARP complex and GARP complex interacting protein 1
  eEF1A lysine and N-terminal methyltransferase
  enolase-phosphatase 1
  EPM2A interacting protein 1
  exportin 1
  FAM161 centrosomal protein A
  FAM161 centrosomal protein B
  family with sequence similarity 110 member A
  family with sequence similarity 184 member A
  family with sequence similarity 50 member B
  Fas associated factor family member 2
  golgi reassembly stacking protein 2
  G-patch domain and KOW motifs
  GTP dependent ribosome recycling factor mitochondrial 2
  HAUS augmin like complex subunit 1
  HEAT repeat containing 1
  hepatocyte growth factor-regulated tyrosine kinase substrate
  histone deacetylase 4
  IKBKB interacting protein
  janus kinase and microtubule interacting protein 2
  kelch like family member 42
  KIAA1217
  kinesin family member 9
  kinesin light chain 3
  KN motif and ankyrin repeat domains 2
  ligand of numb-protein X 1
  LIM domain only 4
  limb development membrane protein 1 like
  MAGE family member L2
  mitochondrial ribosomal protein L1
  mitochondrial ribosomal protein L11
  NDC80 kinetochore complex component
  ninein like
  nuclear receptor 2C2 associated protein
  nuclear receptor subfamily 2 group C member 2
  OTU deubiquitinase 6A
  PICALM interacting mitotic regulator
  pleckstrin homology domain containing A4
  proteasome 26S subunit, non-ATPase 14
  protein kinase N3
  protein phosphatase 1 regulatory subunit 18
  protein prenyltransferase alpha subunit repeat containing 1
  RAB1B, member RAS oncogene family
  RAB4B, member RAS oncogene family
  rabaptin, RAB GTPase binding effector protein 2
  ring finger protein 41
  SH2 domain containing 4A
  signaling lymphocytic activation molecule family member 1
  sodium channel modifier 1
  sperm acrosome associated 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
  syntaxin 11
  syntaxin 6
  taxilin alpha
  taxilin beta
  TBC1 domain family member 1
  TBC1 domain family member 22B
  t-complex 11 like 1
  TEA domain transcription factor 4
  testis specific serine kinase 3
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  THAP domain containing 11
  thioredoxin 2
  thiosulfate sulfurtransferase like domain containing 2
  TNF receptor associated factor 4
  TNF receptor associated factor 6
  transcription elongation factor A N-terminal and central domain containing
  tropomyosin 3
  ubiquitin specific peptidase 2
  vascular endothelial zinc finger 1
  vesicle associated membrane protein 4
  VPS28 subunit of ESCRT-I
  VPS50 subunit of EARP/GARPII complex
  VPS52 subunit of GARP complex
  VPS53 subunit of GARP complex
  VPS54 subunit of GARP complex
  VRK serine/threonine kinase 1
  WASH complex subunit 3
  WT1 associated protein
  zinc finger C2HC-type containing 1C
  zinc finger containing ubiquitin peptidase 1
  zinc finger matrin-type 2
  zinc finger protein 417
  zinc finger protein 587

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.