PA2G4, proliferation-associated 2G4

PA2G4, proliferation-associated 2G4

• This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (EBP1, HG4-1, p38-2G4, proliferation-associated protein 2G4, ErbB-3 binding protein 1, ErbB3-binding protein Ebp1, cell cycle protein p38-2G4 homolog, erbB3-binding protein 1, proliferation-associated 2G4, 38kD, proliferation-associated 2G4, 38kDa,)
• NCBI Gene ID: 5036
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RB85
  UNIPROT ID#>>Q9UQ80
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proliferation-associated 2G4 interacts with:

• 3-phosphoinositide dependent protein kinase 1
  AAR2 splicing factor
  agrin
  aminoacyl tRNA synthetase complex interacting multifunctional protein 1
  autophagy related 101
  autophagy related 16 like 1
  cap methyltransferase 1
  cleavage and polyadenylation specific factor 6
  coiled-coil domain containing 8
  copine 3
  cornulin
  cullin 7
  DET1 and DDB1 associated 1
  DExD/H-box helicase 60
  DExD-box helicase 21
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  DNA topoisomerase I
  DnaJ heat shock protein family (Hsp40) member C8
  elongation factor Tu GTP binding domain containing 2
  eukaryotic elongation factor 2 kinase
  eukaryotic translation initiation factor 2 subunit beta
  eukaryotic translation initiation factor 2A
  eukaryotic translation initiation factor 3 subunit K
  eukaryotic translation initiation factor 3, subunit A
  eukaryotic translation initiation factor 5B
  exosome component 5
  expressed sequence AI837181
  F-box and WD repeat domain containing 7
  forkhead box B1
  forkhead box H1
  forkhead box I2
  G3BP stress granule assembly factor 1
  glycogen phosphorylase L
  high mobility group AT-hook 2
  histone deacetylase 4
  histone deacetylase 5
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inorganic pyrophosphatase 1
  insulin like growth factor 2 mRNA binding protein 2
  insulin like growth factor 2 mRNA binding protein 3
  integrin alpha FG-GAP repeat containing 1
  kinase suppressor of ras 1
  leucine rich repeat kinase 2
  limb development membrane protein 1 like
  mab-21 like 2
  mitochondrial ribosomal protein L12
  mitogen-activated protein kinase kinase kinase 14
  MYC binding protein
  myosin light chain 12B
  N-acetylneuraminate synthase
  negative elongation factor complex member B
  nuclear receptor binding factor 2
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  OFD1 centriole and centriolar satellite protein
  parkin RBR E3 ubiquitin protein ligase
  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
  phosphoethanolamine/phosphocholine phosphatase 1
  PIH1 domain containing 1
  plastin 3
  potassium channel tetramerization domain containing 12
  pre-mRNA processing factor 8
  prohibitin
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase AMP-activated non-catalytic subunit gamma 1
  protein kinase C alpha
  protein kinase C beta
  protein kinase C gamma
  protein kinase N1
  protein phosphatase targeting COQ7
  protein tyrosine phosphatase 4A1
  protein tyrosine phosphatase non-receptor type 6
  PTEN induced kinase 1
  RB transcriptional corepressor 1
  regulatory associated protein of MTOR complex 1
  ribosomal protein L10
  ribosomal protein L11
  ribosomal protein L12
  ribosomal protein L15
  ribosomal protein L18
  ribosomal protein L18a
  ribosomal protein L21
  ribosomal protein L23a
  ribosomal protein L27
  ribosomal protein L28
  ribosomal protein L30
  ribosomal protein L35
  ribosomal protein L4
  ribosomal protein L8
  ribosomal protein lateral stalk subunit P0
  ribosomal protein lateral stalk subunit P2
  ribosomal protein S27 like
  ribosome binding protein 1
  ring finger protein 20
  RRN3 homolog, RNA polymerase I transcription factor
  SERPINE1 mRNA binding protein 1
  serum/glucocorticoid regulated kinase 1
  SH3 domain containing GRB2 like, endophilin B2
  signal recognition particle 68
  SIN3 transcription regulator family member A
  small nuclear ribonucleoprotein polypeptide B2
  small ubiquitin like modifier 4
  spindle and centriole associated protein 1
  splicing factor 3a subunit 1
  splicing factor 3a subunit 3
  staphylococcal nuclease and tudor domain containing 1
  STIP1 homology and U-box containing protein 1
  telomeric repeat binding factor 1
  TNF receptor associated protein 1
  transmembrane p24 trafficking protein 2
  transmembrane p24 trafficking protein 7
  tripartite motif containing 28
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 N
  ubiquitin like 4A
  ubiquitin like modifier activating enzyme 5
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 39
  vesicle associated membrane protein 5
  vimentin
  WW domain containing E3 ubiquitin protein ligase 2
  Yes1 associated transcriptional regulator
  zinc finger protein 207

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