MGMT, O-6-methylguanine-DNA methyltransferase

MGMT, O-6-methylguanine-DNA methyltransferase

• Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]

• Gene Synonyms (methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferase, O6-methylguanine-DNA methyltransferase, methylguanine-DNA methyltransferase,)
• NCBI Gene ID: 4255
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DEE8
  UNIPROT ID#>>P16455
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

O-6-methylguanine-DNA methyltransferase interacts with:

• acidic nuclear phosphoprotein 32 family member E
  alpha tocopherol transfer protein
  cyclin dependent kinase 10
  cyclin dependent kinase 12
  cyclin dependent kinase like 5
  DEAD-box helicase 24
  denticleless E3 ubiquitin protein ligase homolog
  DNA polymerase delta 1, catalytic subunit
  DNA topoisomerase I
  eukaryotic translation initiation factor 3 subunit H
  F-box protein 2
  F-box protein 27
  H2A clustered histone 17
  H2B.W histone 2
  H3.4 histone
  H4 clustered histone 1
  H4 histone 16
  interleukin 25
  mutS homolog 2
  myosin VIIA
  nucleolin
  origin recognition complex subunit 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 3
  pre-mRNA processing factor 4
  prohibitin
  proliferating cell nuclear antigen
  proteasome 26S subunit, non-ATPase 9
  proteasome activator subunit 2
  protein kinase C alpha
  protein kinase C eta
  protein kinase cAMP-activated catalytic subunit alpha
  protein kinase, DNA-activated, catalytic subunit
  protein tyrosine phosphatase non-receptor type 4
  pyruvate kinase M1/2
  ribosomal protein lateral stalk subunit P1
  ribosomal protein S15a
  ring finger protein 8
  SET nuclear proto-oncogene
  signal recognition particle 9
  structural maintenance of chromosomes 1A
  structure specific recognition protein 1
  tubulin alpha 1c
  tubulin beta 4B class IVb
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin B
  ubiquitin like modifier activating enzyme 1
  ubiquitin specific peptidase 19
  valosin containing protein
  vimentin
  Wnt family member 9B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.