MAP2K5, mitogen-activated protein kinase kinase 5

MAP2K5, mitogen-activated protein kinase kinase 5

• The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

• Gene Synonyms (dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAP kinase kinase MEK5b, MAPK/ERK kinase 5, MAPKK 5, MEK 5, HsT17454, MAPKK5, MEK5, PRKMK5,)
• NCBI Gene ID: 5607
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13163
  UNIPROT ID#>>A0A024R5Y2
  UNIPROT ID#>>A0A024R5X5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase 5 interacts with:

• asparaginase and isoaspartyl peptidase 1
  beclin 1
  calcium/calmodulin dependent protein kinase IG
  CDC42 binding protein kinase beta
  cell division cycle 37, HSP90 cochaperone
  chromosome 10 open reading frame 88
  dual specificity phosphatase 21
  fizzy and cell division cycle 20 related 1
  fructosamine 3 kinase
  GLIS family zinc finger 2
  guanylyl cyclase domain containing 1
  large tumor suppressor kinase 2
  ligand of numb-protein X 2
  mitogen-activated protein kinase kinase 5
  mitogen-activated protein kinase kinase 6
  mitogen-activated protein kinase kinase kinase 2
  mitogen-activated protein kinase kinase kinase 3
  nuclear RNA export factor 1
  par-6 family cell polarity regulator alpha
  Raf-1 proto-oncogene, serine/threonine kinase
  ribosomal protein L28
  sequestosome 1
  serine/threonine kinase 11
  STAM binding protein
  TEA domain transcription factor 2
  telomerase reverse transcriptase
  TNF receptor associated factor 7
  TSC complex subunit 1
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  zinc finger protein 426
  zinc finger protein 620

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.