DDOST, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

DDOST, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

• This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]

• Gene Synonyms (dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, advanced glycation end-product receptor 1, advanced glycation endproduct receptor 1, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic), dolichyl-diphosphooligosaccharide-protein glycotransferase, oligosaccharyl transferase 48 kDa subunit, oligosaccharyltransferase 48 kDa subunit, oligosaccharyltransferase subunit 48, AGER1, CDG1R, GATD6, OKSWcl45, OST, OST48, WBP1,)
• NCBI Gene ID: 1650
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P39656
  UNIPROT ID#>>A0A024RAD5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit interacts with:

• ankyrin repeat and SOCS box containing 11
  anterior gradient 2, protein disulphide isomerase family member
  argonaute RISC catalytic component 3
  ATP synthase membrane subunit g
  BRCA1/BRCA2-containing complex subunit 3
  calreticulin 3
  cullin 4A
  cullin 7
  cullin 9
  cytochrome b5 reductase 3
  derlin 1
  DExD-box helicase 39A
  DExD-box helicase 39B
  dual specificity phosphatase 9
  EH domain containing 4
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  ER degradation enhancing alpha-mannosidase like protein 3
  estrogen receptor 2
  FA complementation group D2
  FA complementation group I
  Fas associated factor 1
  F-box protein 6
  fibroblast growth factor receptor 1
  fibronectin 1
  fms related receptor tyrosine kinase 3
  galectin 3
  glutathione S-transferase kappa 1
  H4 clustered histone 1
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein 90 beta family member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 4
  histone deacetylase 5
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
  immunoglobulin binding protein 1
  integrin alpha FG-GAP repeat containing 1
  interleukin enhancer binding factor 2
  jagunal homolog 1
  keratinocyte associated protein 2
  kinectin 1
  limb development membrane protein 1 like
  lysosomal associated membrane protein 1
  MAGE family member A6
  magnesium transporter 1
  malectin
  metaxin 1
  methyltransferase like 14
  microsomal glutathione S-transferase 1
  minichromosome maintenance complex component 2
  mitochondrially encoded cytochrome c oxidase II
  mitogen-activated protein kinase 6
  Mov10 RISC complex RNA helicase
  MYC proto-oncogene, bHLH transcription factor
  neurotrophic receptor tyrosine kinase 1
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  nuclear transport factor 2 like export factor 1
  palmitoyl-protein thioesterase 1
  pleckstrin homology domain containing A4
  POC5 centriolar protein
  presenilin 1
  progestagen associated endometrial protein
  progesterone receptor membrane component 1
  prohibitin
  protein phosphatase 6, catalytic subunit
  protein tyrosine phosphatase receptor type H
  protein tyrosine phosphatase receptor type N
  protein tyrosine phosphatase receptor type O
  protein tyrosine phosphatase receptor type U
  pyrimidinergic receptor P2Y6
  pyruvate dehydrogenase E1 subunit alpha 1
  RecQ like helicase 4
  regulatory factor X associated ankyrin containing protein
  retinol dehydrogenase 13
  ribophorin I
  ribophorin II
  ring finger protein 123
  ring finger protein 4
  SAC1 suppressor of actin mutations 1-like (yeast)
  SEC61 translocon subunit alpha 1
  SEC63 homolog, protein translocation regulator
  secretory carrier membrane protein 3
  serine and arginine rich splicing factor 11
  signal sequence receptor subunit 1
  signal sequence receptor subunit 3
  signal sequence receptor subunit 4
  Sin3A associated protein 18
  solute carrier family 15 member 3
  solute carrier family 25 member 3
  staufen double-stranded RNA binding protein 1
  stimulator of interferon response cGAMP interactor 1
  STT3 oligosaccharyltransferase complex catalytic subunit B
  SUZ12 polycomb repressive complex 2 subunit
  synoviolin 1
  tectonic family member 1
  tectonic family member 2
  tectonic family member 3
  testis expressed 101
  trans-2,3-enoyl-CoA reductase
  trans-golgi network protein 2
  translocase of outer mitochondrial membrane 22
  translocase of outer mitochondrial membrane 40
  translocase of outer mitochondrial membrane 5
  transmembrane BAX inhibitor motif containing 4
  transmembrane protein 41B
  tripartite motif containing 13
  Tu translation elongation factor, mitochondrial
  ubiquilin 2
  ubiquinol-cytochrome c reductase binding protein
  ubiquinol-cytochrome c reductase complex III subunit VII
  ubiquinol-cytochrome c reductase core protein 2
  unc-93 homolog B1, TLR signaling regulator
  VAMP associated protein B and C
  vimentin
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  voltage dependent anion channel 3
  WW domain containing oxidoreductase
  zinc finger protein 598, E3 ubiquitin ligase
  zinc metallopeptidase STE24

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.