FKBP5, FKBP prolyl isomerase 5

FKBP5, FKBP prolyl isomerase 5

• The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

• Gene Synonyms (AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10, peptidyl-prolyl cis-trans isomerase FKBP5, 51 kDa FK506-binding protein, 51 kDa FKBP, 54 kDa progesterone receptor-associated immunophilin, FF1 antigen, FK506 binding protein 5, FKBP-51, HSP90-binding immunophilin, PPIase FKBP5, T-cell FK506-binding protein, androgen-regulated protein 6, peptidylprolyl cis-trans isomerase, rotamase,)
• NCBI Gene ID: 2289
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q2TA84
  UNIPROT ID#>>Q13451
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

FKBP prolyl isomerase 5 interacts with:

• abhydrolase domain containing 15
  activator of HSP90 ATPase activity 1
  AKT serine/threonine kinase 3
  alpha-methylacyl-CoA racemase
  ankyrin repeat and MYND domain containing 2
  argonaute RISC catalytic component 2
  argonaute RISC catalytic component 3
  argonaute RISC component 1
  aurora kinase B
  aurora kinase C
  autophagy related 7
  calcyclin binding protein
  cell division cycle 37 like 1
  cell division cycle 37, HSP90 cochaperone
  clusterin associated protein 1
  cyclin dependent kinase 11A
  cyclin dependent kinase 13
  cyclin dependent kinase 15
  cyclin dependent kinase 18
  cyclin dependent kinase like 1
  cyclin dependent kinase like 4
  cysteine and histidine rich domain containing 1
  dicer 1, ribonuclease III
  DnaJ heat shock protein family (Hsp40) member B6
  egl-9 family hypoxia inducible factor 1
  EPM2A glucan phosphatase, laforin
  F-box and WD repeat domain containing 7
  glomulin, FKBP associated protein
  glycogen phosphorylase L
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein family A (Hsp70) member 4
  heat shock transcription factor 1
  heat shock transcription factor 4
  heterogeneous nuclear ribonucleoprotein L
  HGH1 homolog
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inhibitor of nuclear factor kappa B kinase subunit beta
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  insulin receptor substrate 4
  integrin linked kinase
  kinesin family binding protein
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat containing 40
  leucine rich repeat kinase 1
  LIM domain kinase 2
  lysine demethylase 6B
  MAGE family member A11
  MAGE family member D2
  Max protein
  microtubule associated protein tau
  minichromosome maintenance complex binding protein
  minichromosome maintenance complex component 3
  minichromosome maintenance complex component 4
  minichromosome maintenance complex component 5
  mitogen-activated protein kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase 6
  MOS proto-oncogene, serine/threonine kinase
  myotubularin related protein 7
  neurotrophic receptor tyrosine kinase 1
  NIMA related kinase 11
  nuclear distribution C, dynein complex regulator
  nuclear receptor subfamily 2 group C member 2
  nuclear receptor subfamily 3 group C member 1
  nuclear receptor subfamily 3 group C member 2
  NudC domain containing 3
  O-GlcNAcase
  opioid growth factor receptor
  patatin like phospholipase domain containing 2
  PDLIM1 interacting kinase 1 like
  PH domain and leucine rich repeat protein phosphatase 1
  PH domain and leucine rich repeat protein phosphatase 2
  phosphatase and tensin homolog
  pipecolic acid and sarcosine oxidase
  progesterone receptor
  programmed cell death 2
  prostaglandin E synthase 3
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase cAMP-activated catalytic subunit beta
  protein serine kinase H2
  protein tyrosine phosphatase 4A3
  pyrimidinergic receptor P2Y6
  receptor interacting serine/threonine kinase 3
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  ribosomal protein S6 kinase B2
  RPA1 related single stranded DNA binding protein, X-linked
  serine/threonine kinase 11
  serine/threonine kinase 35
  serine/threonine kinase 40
  serum/glucocorticoid regulated kinase 1
  serum/glucocorticoid regulated kinase 2
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  stress induced phosphoprotein 1
  TERF1 interacting nuclear factor 2
  testis specific serine kinase 6
  tetratricopeptide repeat domain 4
  TLE family member 3, transcriptional corepressor
  TNF receptor associated protein 1
  transmembrane p24 trafficking protein 2
  tripartite motif containing 25
  tripartite motif containing 28
  tropomyosin 3
  tubulin alpha 1a
  tubulin epsilon and delta complex 1
  ubiquitin specific peptidase 49
  ubiquitin specific peptidase 7
  unc-51 like kinase 3
  WD repeat domain 90
  X-ray repair cross complementing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.