MECOM, MDS1 and EVI1 complex locus

MECOM, MDS1 and EVI1 complex locus

• The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

• Gene Synonyms (AML1-EVI-1, EVI1, KMT8E, MDS1, MDS1-EVI1, PRDM3, RUSAT2, histone-lysine N-methyltransferase MECOM, AML1-EVI-1 fusion protein, MDS1 and EVI1 complex locus protein EVI1, MDS1 and EVI1 complex locus protein MDS1, PR domain 3, ecotropic virus integration site 1 protein homolog, myelodysplasia syndrome-associated protein 1, oncogene EVI1, zinc finger protein Evi1,)
• NCBI Gene ID: 2122
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13465
  UNIPROT ID#>>Q03112
  UNIPROT ID#>>A0A0C3SFZ7
  UNIPROT ID#>>C7FEN9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MDS1 and EVI1 complex locus interacts with:

• actin related protein 1A
  actin related protein 2
  adaptor related protein complex 1 subunit mu 1
  A-kinase anchoring protein 8
  A-kinase anchoring protein 8 like
  AT-hook containing transcription factor 1
  ATP binding cassette subfamily D member 3
  ATP binding cassette subfamily F member 2
  BAG cochaperone 2
  bromodomain adjacent to zinc finger domain 1B
  caveolae associated protein 1
  chloride intracellular channel 3
  chromobox 3
  COPI coat complex subunit epsilon
  COPI coat complex subunit gamma 1
  cytochrome c oxidase subunit 5A
  cytoplasmic FMR1 interacting protein 1
  cytosolic iron-sulfur assembly component 2B
  DEAD-box helicase 17
  DEAD-box helicase 24
  DEAD-box helicase 27
  DEAD-box helicase 47
  DEAD-box helicase 49
  DnaJ heat shock protein family (Hsp40) member A3
  DnaJ heat shock protein family (Hsp40) member B6
  DnaJ heat shock protein family (Hsp40) member C9
  erythroblast membrane associated protein (Scianna blood group)
  euchromatic histone lysine methyltransferase 2
  eukaryotic translation initiation factor 3 subunit C
  eukaryotic translation initiation factor 3 subunit D
  eukaryotic translation initiation factor 3 subunit E
  eukaryotic translation initiation factor 3 subunit L
  filamin C
  FMR1 autosomal homolog 2
  forkhead box J2
  FtsJ RNA 2'-O-methyltransferase 3
  G protein nucleolar 2
  G protein nucleolar 3
  galectin 3 binding protein
  GATA zinc finger domain containing 2A
  GATA zinc finger domain containing 2B
  glutamate rich WD repeat containing 1
  GTP binding protein 4
  H1.2 linker histone, cluster member
  H3 clustered histone 1
  H3 clustered histone 14
  H4 clustered histone 1
  HCLS1 associated protein X-1
  heat shock protein family B (small) member 1
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A/B
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein U like 2
  HIC ZBTB transcriptional repressor 1
  histone deacetylase 1
  histone deacetylase 2
  histone deacetylase 4
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
  IQ motif containing GTPase activating protein 1
  IQ motif containing GTPase activating protein 3
  karyopherin subunit alpha 2
  karyopherin subunit beta 1
  KH RNA binding domain containing, signal transduction associated 1
  L3MBTL histone methyl-lysine binding protein 1
  lamin B receptor
  lysine acetyltransferase 2B
  macroH2A.1 histone
  MAGE family member D2
  MAP7 domain containing 1
  matrin 3
  MDS1 and EVI1 complex locus
  mediator complex subunit 23
  metastasis associated 1
  metastasis associated 1 family member 2
  methyl-CpG binding domain protein 3
  microtubule associated protein 1B
  minichromosome maintenance complex component 7
  Mtr4 exosome RNA helicase
  MYB binding protein 1a
  myosin IB
  myosin IC
  N-acetyltransferase 10
  NADH:ubiquinone oxidoreductase subunit A9
  NLR family pyrin domain containing 14
  NOC3 like DNA replication regulator
  non-SMC condensin I complex subunit D2
  non-SMC condensin I complex subunit H
  NOP56 ribonucleoprotein
  NOP58 ribonucleoprotein
  nucleoporin 133
  nucleoporin 160
  nucleoporin 205
  nucleoporin 93
  nucleosome assembly protein 1 like 1
  PAF1 homolog, Paf1/RNA polymerase II complex component
  PC4 and SFRS1 interacting protein 1
  PHD finger protein 6
  phosphofructokinase, liver type
  phosphofructokinase, platelet
  phosphoglycerate dehydrogenase
  phosphoinositide-3-kinase regulatory subunit 3
  pinin, desmosome associated protein
  pleiotropic regulator 1
  pre-mRNA processing factor 19
  prolyl 4-hydroxylase subunit alpha 1
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 3
  protein arginine methyltransferase 1
  protein inhibitor of activated STAT 4
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 6 regulatory subunit 3
  pumilio RNA binding family member 3
  pyruvate dehydrogenase E1 subunit beta
  RAB GTPase activating protein 1 like
  Ras homolog, mTORC1 binding
  RB binding protein 4, chromatin remodeling factor
  RB binding protein 7, chromatin remodeling factor
  replication factor C subunit 1
  reticulocalbin 2
  Rho/Rac guanine nucleotide exchange factor 2
  ribophorin I
  ribophorin II
  ribosomal protein L5
  ribosomal protein S15
  ribosomal protein S26
  ribosomal protein S27a
  ribosomal protein S7
  ribosome biogenesis regulator 1 homolog
  RNA binding fox-1 homolog 2
  RNA binding motif protein 14
  RNA binding motif protein 15
  RNA binding motif protein 39
  RNA transcription, translation and transport factor
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  SAM pointed domain containing ETS transcription factor
  sequestosome 1
  serine and arginine rich splicing factor 1
  serine and arginine rich splicing factor 6
  serine and arginine rich splicing factor 9
  sirtuin 1
  SMAD family member 1
  SMAD family member 2
  SMAD family member 3
  SMAD family member 4
  small nuclear ribonucleoprotein D1 polypeptide
  solute carrier family 25 member 11
  solute carrier family 25 member 13
  solute carrier family 3 member 2
  SON DNA and RNA binding protein
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  SPT16 homolog, facilitates chromatin remodeling subunit
  SRY-box transcription factor 2
  structural maintenance of chromosomes 1A
  structure specific recognition protein 1
  succinate-CoA ligase GDP-forming subunit beta
  suppressor of variegation 3-9 homolog 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  t-complex 1
  THO complex 2
  TNFAIP3 interacting protein 2
  transducin beta like 3
  translocase of inner mitochondrial membrane 44
  translocase of inner mitochondrial membrane 50
  Tu translation elongation factor, mitochondrial
  tubulin alpha 1a
  tubulin beta 6 class V
  tumor protein p53
  ubiquinol-cytochrome c reductase hinge protein
  ubiquitin conjugating enzyme E2 I
  UTP4 small subunit processome component
  vir like m6A methyltransferase associated
  WD repeat domain 74
  Y-box binding protein 3
  zinc finger CCHC-type containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.