DVL2, dishevelled segment polarity protein 2

DVL2, dishevelled segment polarity protein 2

• This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

• Gene Synonyms (segment polarity protein dishevelled homolog DVL-2, dishevelled 2 (homologous to Drosophila dsh), dishevelled, dsh homolog 2,)
• NCBI Gene ID: 1856
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14641
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dishevelled segment polarity protein 2 interacts with:

• adaptor related protein complex 1 subunit mu 1
  ADP ribosylation factor like GTPase 6 interacting protein 4
  A-kinase anchoring protein 9
  arginine and serine rich coiled-coil 1
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  autophagy and beclin 1 regulator 1
  autophagy related 14
  autophagy related 16 like 1
  axin 1
  BAG cochaperone 3
  BEN domain containing 7
  bromo adjacent homology domain containing 1
  caspase recruitment domain family member 9
  caveolae associated protein 1
  caveolae associated protein 2
  centrosomal protein 128
  centrosomal protein 135
  centrosomal protein 19
  centrosomal protein 44
  chromosome 19 open reading frame 33
  cleavage and polyadenylation specific factor 7
  coiled-coil domain containing 33
  cordon-bleu WH2 repeat protein like 1
  cullin 3
  CWC25 spliceosome associated protein homolog
  CWF19 like cell cycle control factor 2
  DEAD-box helicase 41
  defective in cullin neddylation 1 domain containing 1
  developmental pluripotency associated 2
  dishevelled associated activator of morphogenesis 1
  dishevelled binding antagonist of beta catenin 1
  dishevelled segment polarity protein 2
  dishevelled segment polarity protein 3
  DNA damage inducible 1 homolog 1
  DNA polymerase iota
  dynein light chain Tctex-type 1
  early endosome antigen 1
  egl-9 family hypoxia inducible factor 3
  ELAV like RNA binding protein 1
  ELKS/RAB6-interacting/CAST family member 1
  elongin A2
  enkurin domain containing 1
  epidermal growth factor receptor pathway substrate 15
  epidermal growth factor receptor pathway substrate 15 like 1
  epsin 1
  eukaryotic translation initiation factor 1B
  exportin 1
  FAM161 centrosomal protein A
  family with sequence similarity 90 member A1
  F-box and leucine rich repeat protein 17
  forkhead box K1
  forkhead box K2
  frizzled class receptor 4
  frizzled class receptor 5
  GABA type A receptor associated protein like 1
  GABA type A receptor-associated protein
  germ cell-less 2, spermatogenesis associated
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  golgin A2
  GRB2 related adaptor protein 2
  growth factor receptor bound protein 2
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  hook microtubule tethering protein 3
  huntingtin interacting protein 1
  insulin receptor substrate 1
  insulin receptor substrate 2
  interactor of HORMAD1 1
  IQ motif containing GTPase activating protein 1
  itchy E3 ubiquitin protein ligase
  kelch like family member 12
  KIAA0753
  lebercilin LCA5
  leucine rich repeat containing 4C
  leucine rich repeat kinase 2
  LIM domain only 3
  limb development membrane protein 1 like
  LYN proto-oncogene, Src family tyrosine kinase
  mago homolog B, exon junction complex subunit
  mediator complex subunit 4
  microspherule protein 1
  microtubule associated protein 1 light chain 3 alpha
  mitogen-activated protein kinase kinase kinase 1
  NBAS subunit of NRZ tethering complex
  NEDD4 like E3 ubiquitin protein ligase
  neurotrophic receptor tyrosine kinase 1
  NHL repeat containing E3 ubiquitin protein ligase 1
  nuclear mitotic apparatus protein 1
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 2
  nucleolar protein 12
  nucleoporin 62 C-terminal like
  olfactomedin 2
  OTU deubiquitinase with linear linkage specificity
  outer dense fiber of sperm tails 2
  phosphoinositide-3-kinase regulatory subunit 4
  phospholipase A2 group XIIA
  pleckstrin homology domain containing A4
  pleckstrin homology like domain family B member 2
  polo like kinase 1
  pre-mRNA processing factor 3
  pre-mRNA processing factor 31
  proteasome 20S subunit alpha 1
  proteasome 20S subunit alpha 7
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 8
  proteasome inhibitor subunit 1
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase C alpha
  protein kinase C beta
  protein kinase C gamma
  protein phosphatase 1 regulatory subunit 16B
  protein phosphatase, Mg2+/Mn2+ dependent 1A
  proteoglycan 2, pro eosinophil major basic protein
  pterin-4 alpha-carbinolamine dehydratase 1
  Rac family small GTPase 1
  RAN binding protein 9
  Ras association domain family member 10
  Ras association domain family member 9
  Rho guanine nucleotide exchange factor 39
  Rhox homeobox family member 2
  ring finger protein 185
  ring finger protein 41
  ring finger protein 43
  RNA binding fox-1 homolog 1
  RNA binding protein with serine rich domain 1
  RNA binding protein, mRNA processing factor
  RPGRIP1 like
  RUN and SH3 domain containing 1
  SAS-6 centriolar assembly protein
  sequestosome 1
  serine/threonine kinase 11
  sirtuin 1
  Smad nuclear interacting protein 1
  SMAD specific E3 ubiquitin protein ligase 2
  SMAD specific E3 ubiquitin protein ligase 2
  SNF8 subunit of ESCRT-II
  sodium channel modifier 1
  sorbin and SH3 domain containing 3
  SSX family member 2 interacting protein
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  THAP domain containing 1
  threonyl-tRNA synthetase 1
  TNF alpha induced protein 1
  TNF receptor associated factor 2
  TRAF interacting protein with forkhead associated domain
  tripartite motif containing 29
  tropomyosin 3
  tumor protein p53
  tyrosyl-DNA phosphodiesterase 2
  U2 small nuclear RNA auxiliary factor 2
  UBA domain containing 1
  ubiquitin conjugating enzyme E2 D3
  ubiquitin interaction motif containing 1
  ubiquitin specific peptidase 5
  ubiquitin specific peptidase 9 X-linked
  VANGL planar cell polarity protein 1
  von Hippel-Lindau tumor suppressor
  WASP actin nucleation promoting factor
  WD repeat domain 26
  WT1 transcription factor
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  WW domain containing transcription regulator 1
  YES proto-oncogene 1, Src family tyrosine kinase
  zinc and ring finger 3
  zinc finger and BTB domain containing 17
  zinc finger and BTB domain containing 48
  zinc finger and BTB domain containing 8A
  zinc finger and BTB domain containing 8B
  zinc finger CCCH-type and G-patch domain containing
  zinc finger protein 165
  zinc finger protein 250
  zinc finger protein 263
  zinc finger protein 410
  zinc finger protein 581

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.