CLTC, clathrin heavy chain

CLTC, clathrin heavy chain

• Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]

• Gene Synonyms (clathrin heavy chain 1, clathrin heavy chain on chromosome 17, clathrin, heavy polypeptide (Hc), clathrin, heavy polypeptide-like 2, CHC, CHC17, CLH-17, CLTCL2, Hc, MRD56,)
• NCBI Gene ID: 1213
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087WVQ6
  UNIPROT ID#>>Q00610
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

clathrin heavy chain interacts with:

• 5-hydroxytryptamine receptor 6
  AAR2 splicing factor
  actin, beta
  adaptor related protein complex 3 subunit beta 1
  adaptor related protein complex 3 subunit beta 2
  adaptor related protein complex 3 subunit delta 1
  agrin
  anillin actin binding protein
  anterior gradient 2, protein disulphide isomerase family member
  AP2 associated kinase 1
  ariadne RBR E3 ubiquitin protein ligase 2
  aristaless related homeobox
  armadillo repeat containing X-linked 3
  ataxin 3
  ATPase H+ transporting V0 subunit d1
  ATPase H+ transporting V1 subunit D
  autophagy related 16 like 1
  biogenesis of lysosomal organelles complex 1 subunit 1
  BMP2 inducible kinase
  bromodomain containing 1
  BTB domain containing 3
  calmodulin-like 3
  carboxypeptidase vitellogenic like
  casein kinase 1 alpha 1
  casein kinase 1 epsilon
  CD2-associated protein
  CDGSH iron sulfur domain 1
  CDK5 regulatory subunit associated protein 2
  cell division cycle 73
  centriolin
  centrosomal protein 97
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 6B
  charged multivesicular body protein 1A
  charged multivesicular body protein 1B
  charged multivesicular body protein 4B
  chromosome 10 open reading frame 88
  clathrin heavy chain
  clathrin heavy chain like 1
  clathrin interactor 1
  cleavage and polyadenylation specific factor 7
  coiled-coil domain containing 115
  coiled-coil domain containing 47
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  coronin, actin binding protein 1C
  CREB regulated transcription coactivator 2
  CREB regulated transcription coactivator 3
  cullin 1
  cullin 2
  cullin 3
  cullin 3
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin G associated kinase
  CYLD lysine 63 deubiquitinase
  cytochrome c1
  DAB adaptor protein 2
  DEAH-box helicase 38
  decapping mRNA 1A
  defective in cullin neddylation 1 domain containing 1
  DENN domain containing 1A
  DnaJ heat shock protein family (Hsp40) member A3
  DnaJ heat shock protein family (Hsp40) member C6
  DnaJ heat shock protein family (Hsp40) member C7
  dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
  drebrin 1
  dual serine/threonine and tyrosine protein kinase
  dual specificity tyrosine phosphorylation regulated kinase 1A
  dynactin 3
  dynactin subunit 1
  E1A binding protein p300
  EGF like domain multiple 7
  EH domain containing 1
  EH domain containing 2
  EH domain containing 4
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  enhancer of mRNA decapping 3
  enhancer of mRNA decapping 4
  EPH receptor A2
  epidermal growth factor receptor pathway substrate 15
  epsin 1
  epsin 2
  erbb2 interacting protein
  erb-b2 receptor tyrosine kinase 2
  ERH mRNA splicing and mitosis factor
  estrogen receptor 1
  ETS transcription factor ERG
  eukaryotic translation initiation factor 6
  FA complementation group D2
  family with sequence similarity 83 member A
  family with sequence similarity 83 member B
  family with sequence similarity 83 member H
  Fas binding factor 1
  FAST kinase domains 2
  F-box and leucine-rich repeat protein 16
  F-box and WD repeat domain containing 11
  F-box protein 6
  F-box protein 7
  FCH and mu domain containing endocytic adaptor 2
  FCH domain only 2
  fibronectin 1
  filamin A
  filamin, beta
  FYN proto-oncogene, Src family tyrosine kinase
  G2 and S-phase expressed 1
  gap junction protein alpha 1
  gap junction protein beta 5
  glutamate ionotropic receptor NMDA type subunit 1
  glutamate ionotropic receptor NMDA type subunit 2D
  glutamate rich WD repeat containing 1
  glutaminyl-tRNA synthetase 1
  glycogen synthase kinase 3 beta
  golgi associated, gamma adaptin ear containing, ARF binding protein 1
  golgi associated, gamma adaptin ear containing, ARF binding protein 2
  golgi associated, gamma adaptin ear containing, ARF binding protein 3
  growth factor receptor bound protein 2
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 4
  heat shock protein family A (Hsp70) member 8
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  helicase with zinc finger
  hepatocyte growth factor-regulated tyrosine kinase substrate
  heterogeneous nuclear ribonucleoprotein A1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  huntingtin
  huntingtin interacting protein 1
  huntingtin interacting protein 1 related
  importin 5
  inhibitor of nuclear factor kappa B kinase subunit beta
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  integrin subunit alpha 4
  intersectin 1
  IQ motif containing GTPase activating protein 1
  ISG15 ubiquitin like modifier
  IST1 factor associated with ESCRT-III
  junction plakoglobin
  keratin 17
  kinase D interacting substrate 220
  KIT proto-oncogene, receptor tyrosine kinase
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat containing G protein-coupled receptor 4
  leucine rich repeat kinase 2
  LIM and SH3 protein 1
  LIM domain and actin binding 1
  LIM domain and actin binding 1
  limb development membrane protein 1 like
  low density lipoprotein receptor adaptor protein 1
  major vault protein
  MCC regulator of WNT signaling pathway
  MDS1 and EVI1 complex locus
  meiosis regulator and mRNA stability factor 1
  metal regulatory transcription factor 1
  methylphosphate capping enzyme
  microtubule associated protein 1 light chain 3 alpha
  microtubule associated protein RP/EB family member 1
  microtubule associated scaffold protein 1
  microtubule interacting and trafficking domain containing 1
  minichromosome maintenance complex component 2
  mitochondrial carrier 2
  mitochondrially encoded cytochrome c oxidase II
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase kinase 1
  mitogen-activated protein kinase kinase kinase 10
  mitogen-activated protein kinase kinase kinase 7
  MYB proto-oncogene like 2
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 9
  myosin IC
  myosin VI
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  NADH:ubiquinone oxidoreductase core subunit S1
  NADH:ubiquinone oxidoreductase subunit A9
  NADH:ubiquinone oxidoreductase subunit B9
  NECAP endocytosis associated 1
  NEDD8 ubiquitin like modifier
  nephrocystin 1
  neurocalcin delta
  neurotrophic receptor tyrosine kinase 1
  NHS-like 1
  NLR family pyrin domain containing 1
  N-myc downstream regulated 1
  nuclear factor, erythroid derived 2, like 2
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  nucleophosmin 1
  NUMB endocytic adaptor protein
  obscurin like cytoskeletal adaptor 1
  OCRL inositol polyphosphate-5-phosphatase
  OFD1 centriole and centriolar satellite protein
  palmitoyl-protein thioesterase 1
  patched 1
  PAX interacting protein 1
  paxillin
  PDZ and LIM domain 7
  peptidyl-tRNA hydrolase 2
  pericentriolar material 1
  phosphatidylinositol binding clathrin assembly protein
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
  PIH1 domain containing 1
  pituitary tumor-transforming gene 1
  plakophilin 3
  plakophilin 4
  platelet activating factor receptor
  platelet derived growth factor receptor beta
  pleckstrin homology domain containing A2
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing A5
  POC1 centriolar protein B
  POC5 centriolar protein
  poly(A) specific ribonuclease subunit PAN2
  PR/SET domain 16
  pre-mRNA processing factor 8
  prohibitin
  prohibitin 2
  protein kinase C zeta
  protein kinase cAMP-activated catalytic subunit alpha
  protein kinase cAMP-dependent type II regulatory subunit alpha
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 2 scaffold subunit Abeta
  protein phosphatase methylesterase 1
  protein tyrosine phosphatase non-receptor type 23
  protein tyrosine phosphatase, non-receptor type 23
  PTEN induced kinase 1
  RAB11A, member RAS oncogene family
  RAB5B, member RAS oncogene family
  Rac family small GTPase 1
  RAD18 E3 ubiquitin protein ligase
  RALBP1 associated Eps domain containing 1
  RAN binding protein 2
  RAN binding protein 6
  RecQ like helicase 4
  replication protein A1
  replication protein A2
  replication protein A3
  ribophorin I
  ribosomal protein SA
  ring finger and CCCH-type domains 2
  ring finger protein 123
  ring finger protein 4
  RIO kinase 1
  RNA binding motif protein 14
  RPTOR independent companion of MTOR complex 2
  SAMM50 sorting and assembly machinery component
  SCY1 like pseudokinase 2
  SEC13 homolog, nuclear pore and COPII coat complex component
  SEC16 homolog A, endoplasmic reticulum export factor
  Sec23 homolog A, COPII coat complex component
  SEC24 homolog B, COPII coat complex component
  SEC24 homolog C, COPII coat complex component
  Sec24 related gene family, member C (S. cerevisiae)
  SH3 domain containing kinase binding protein 1
  SHC adaptor protein 1
  signal sequence receptor subunit 3
  signal transducing adaptor molecule
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 1
  small ArfGAP 1
  small ArfGAP 1
  solute carrier family 25 member 3
  solute carrier family 35 member B2
  sorbin and SH3 domain containing 2
  sorting nexin 5
  sorting nexin 9
  spartin
  spastin
  spindle apparatus coiled-coil protein 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  STAM binding protein
  STAM binding protein like 1
  staufen double-stranded RNA binding protein 1
  sterol O-acyltransferase 1
  stomatin
  stonin 2
  striatin, calmodulin binding protein 3
  supervillin
  synaptojanin 1
  synaptopodin
  synaptosome associated protein 91
  syntaxin 2
  synuclein alpha
  target of myb1 like 1 membrane trafficking protein
  target of myb1 like 2 membrane trafficking protein
  target of myb1 membrane trafficking protein
  testin LIM domain protein
  testis expressed 101
  tet methylcytosine dioxygenase 2
  thymopoietin
  TNFAIP3 interacting protein 2
  TRAF-type zinc finger domain containing 1
  trans-2,3-enoyl-CoA reductase
  transcription factor 7 like 2
  transcription factor AP-2 alpha
  transcription factor binding to IGHM enhancer 3
  transcription factor CP2
  translocase of outer mitochondrial membrane 22
  transmembrane and coiled-coil domains 1
  trinucleotide repeat containing adaptor 6A
  trinucleotide repeat containing adaptor 6B
  tripartite motif containing 28
  trophinin associated protein
  tropomodulin 3
  tropomyosin 1, alpha
  Tu translation elongation factor, mitochondrial
  tumor necrosis factor
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine kinase non receptor 1
  tyrosine kinase non receptor 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquinol-cytochrome c reductase binding protein
  ubiquinol-cytochrome c reductase complex III subunit VII
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L3
  ubiquitin like 4A
  ubiquitin protein ligase E3A
  unk zinc finger
  USO1 vesicle docking factor
  USO1 vesicle transport factor
  vascular cell adhesion molecule 1
  vesicle transport through interaction with t-SNAREs 1B
  vinculin
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  voltage dependent anion channel 3
  WNK lysine deficient protein kinase 1
  WW domain containing E3 ubiquitin protein ligase 2
  xenotropic and polytropic retrovirus receptor 1
  X-ray repair cross complementing 6
  Yes1 associated transcriptional regulator
  zinc finger FYVE-type containing 9
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746
  zinc metallopeptidase STE24

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.