DLG4, discs large MAGUK scaffold protein 4

DLG4, discs large MAGUK scaffold protein 4

• This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (disks large homolog 4, Tax interaction protein 15, discs large homolog 4, post-synaptic density protein 95, synapse-associated protein 90, MRD62, PSD95, SAP-90, SAP90,)
• NCBI Gene ID: 1742
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P78352
  UNIPROT ID#>>B7Z647
  UNIPROT ID#>>B9EGL1
  UNIPROT ID#>>B7Z4H2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

discs large MAGUK scaffold protein 4 interacts with:

• 5-hydroxytryptamine receptor 2A
  5-hydroxytryptamine receptor 2C
  acid sensing ion channel subunit 3
  ADAM metallopeptidase domain 22
  adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  adhesion G protein-coupled receptor L1
  A-kinase anchoring protein 5
  brain enriched guanylate kinase associated
  calcium voltage-gated channel auxiliary subunit gamma 2
  calcium/calmodulin dependent serine protein kinase
  CD46 molecule
  citron rho-interacting serine/threonine kinase
  connector enhancer of kinase suppressor of Ras 2
  contactin associated protein 2
  cullin 3
  CXXC repeat containing interactor of PDZ3 domain
  discs large MAGUK scaffold protein 4
  DLG associated protein 1
  DLG associated protein 2
  DLG associated protein 3
  DLG associated protein 4
  dual specificity phosphatase 10
  dynein light chain LC8-type 1
  dynein light chain LC8-type 2
  ELAV like RNA binding protein 1
  ephrin B2
  erbb2 interacting protein
  erb-b2 receptor tyrosine kinase 2
  erb-b2 receptor tyrosine kinase 4
  exocyst complex component 4
  frizzled class receptor 1
  frizzled class receptor 2
  frizzled class receptor 4
  frizzled class receptor 7
  FYN proto-oncogene, Src family tyrosine kinase
  G protein subunit gamma 13
  glutamate ionotropic receptor AMPA type subunit 2
  glutamate ionotropic receptor AMPA type subunit 3
  glutamate ionotropic receptor kainate type subunit 1
  glutamate ionotropic receptor kainate type subunit 2
  glutamate ionotropic receptor kainate type subunit 5
  glutamate ionotropic receptor NMDA type subunit 1
  glutamate ionotropic receptor NMDA type subunit 2A
  glutamate ionotropic receptor NMDA type subunit 2B
  glutamate ionotropic receptor NMDA type subunit 2C
  glutamate ionotropic receptor NMDA type subunit 2D
  glutamate ionotropic receptor NMDA type subunit 3A
  glutamate ionotropic receptor NMDA type subunit 3B
  glutaminase 2
  guanine deaminase
  guanylate cyclase 1 soluble subunit alpha 2
  hepatocyte growth factor-regulated tyrosine kinase substrate
  huntingtin
  interleukin 13 receptor subunit alpha 1
  KH RNA binding domain containing, signal transduction associated 1
  kinesin family member 13B
  kinesin family member 1B
  LDL receptor related protein 1
  LDL receptor related protein 2
  LDL receptor related protein 8
  leucine rich glioma inactivated 1
  leucine rich repeat and fibronectin type III domain containing 1
  leucine rich repeat containing 1
  leucine rich repeat containing 7
  lin-7 homolog A, crumbs cell polarity complex component
  lin-7 homolog B, crumbs cell polarity complex component
  LYN proto-oncogene, Src family tyrosine kinase
  MDM2 proto-oncogene
  mediator complex subunit 28
  microtubule associated protein 1A
  mitogen-activated protein kinase 12
  mitogen-activated protein kinase kinase kinase 10
  mitogen-activated protein kinase kinase kinase 11
  myelin basic protein
  NADPH dependent diflavin oxidoreductase 1
  NCK interacting protein with SH3 domain
  neuregulin 1
  neuroligin 1
  neuroligin 2
  neuroligin 3
  neuroligin 4 X-linked
  nitric oxide synthase 1
  parkin RBR E3 ubiquitin protein ligase
  potassium inwardly rectifying channel subfamily J member 10
  potassium inwardly rectifying channel subfamily J member 12
  potassium inwardly rectifying channel subfamily J member 2
  potassium inwardly rectifying channel subfamily J member 4
  potassium voltage-gated channel subfamily A member 1
  potassium voltage-gated channel subfamily A member 2
  potassium voltage-gated channel subfamily A member 3
  potassium voltage-gated channel subfamily A member 4
  potassium voltage-gated channel subfamily A member 5
  potassium voltage-gated channel subfamily D member 2
  protein kinase C alpha
  protein tyrosine kinase 2 beta
  protein tyrosine phosphatase non-receptor type 5
  protein tyrosine phosphatase receptor type G
  protocadherin 10
  RAD23 homolog A, nucleotide excision repair protein
  Rho GTPase activating protein 32
  ribosomal protein S6 kinase A1
  semaphorin 4B
  semaphorin 4C
  semaphorin 4G
  SH3 and multiple ankyrin repeat domains 1
  SH3 and multiple ankyrin repeat domains 2
  signal induced proliferation associated 1 like 1
  small proline rich protein 2A
  sodium voltage-gated channel alpha subunit 5
  SRC proto-oncogene, non-receptor tyrosine kinase
  ssemaphorin 4F
  synaptic Ras GTPase activating protein 1
  tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
  TNF receptor associated factor 6
  trafficking regulator and scaffold protein tamalin
  Wnt family member 3A
  YES proto-oncogene 1, Src family tyrosine kinase
  zinc finger DHHC-type palmitoyltransferase 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.