ENO1, enolase 1

ENO1, enolase 1

• This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]

• Gene Synonyms (ENO1L1, HEL-S-17, MPB1, NNE, PPH, alpha-enolase, c-myc promoter-binding protein-1, 2-phospho-D-glycerate hydro-lyase, MYC promoter-binding protein 1, alpha enolase like 1, enolase 1, (alpha), enolase-alpha, epididymis secretory protein Li 17, non-neural enolase, phosphopyruvate hydratase, plasminogen-binding protein, tau-crystallin,)
• NCBI Gene ID: 2023
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R4F1
  UNIPROT ID#>>P06733
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

enolase 1 interacts with:

• 5'-3' exoribonuclease 2
  AAR2 splicing factor
  abl interactor 2
  acetyl-CoA acyltransferase 2
  actin related protein 2/3 complex subunit 4
  activating signal cointegrator 1 complex subunit 3
  activator of HSP90 ATPase activity 1
  agrin
  AKT interacting protein
  aldehyde dehydrogenase 4 family member A1
  aldo-keto reductase family 1 member B15
  ankyrin repeat domain 40
  anterior gradient 2, protein disulphide isomerase family member
  ataxin 3
  ATP/GTP binding protein 1
  ATPase H+ transporting accessory protein 2
  autophagy related 16 like 1
  B cell receptor associated protein 31
  basic helix-loop-helix family member e40
  beta-transducin repeat containing E3 ubiquitin protein ligase
  bromodomain containing 7
  CDC42 small effector 1
  cell division cycle 73
  centrosomal protein 192
  centrosomal protein 250
  chaperonin containing TCP1 subunit 7
  checkpoint kinase 2
  chloride intracellular channel 4
  chromosome 1 open reading frame 198
  chromosome 8 open reading frame 33
  clathrin heavy chain like 1
  cleavage and polyadenylation specific factor 7
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  cullin 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  C-X-C motif chemokine ligand 2
  cytochrome b5 type B
  cytokine receptor like factor 1
  death effector domain containing
  decapping enzyme, scavenger
  developmental pluripotency-associated 3
  DExH-box helicase 30
  diaphanous related formin 3
  dimethylarginine dimethylaminohydrolase 2
  diphthamide biosynthesis 5
  DNA ligase 4
  DNA polymerase alpha 1, catalytic subunit
  DNA polymerase epsilon 3, accessory subunit
  doublecortin like kinase 2
  EBP cholestenol delta-isomerase
  EGF containing fibulin extracellular matrix protein 1
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  endonuclease domain containing 1
  endoplasmic reticulum aminopeptidase 1
  enolase 2
  enolase 3
  ER membrane protein complex subunit 1
  ergosterol biosynthesis 28 homolog
  estrogen receptor 2
  exportin 7
  ezrin
  FA complementation group A
  FA complementation group D2
  family with sequence similarity 136 member A
  Fas associated factor 1
  Fas associated factor family member 2
  FAT atypical cadherin 4
  fatty acid binding protein 5
  F-box and WD repeat domain containing 7
  F-box protein 25
  F-box protein 5
  F-box protein 6
  fibrillarin
  fibronectin 1
  filamin C
  FKBP prolyl isomerase 1A
  FKBP prolyl isomerase 1B
  FKBP prolyl isomerase 2
  FKBP prolyl isomerase 7
  flap structure-specific endonuclease 1
  fumarate hydratase
  FUS RNA binding protein
  FYN proto-oncogene, Src family tyrosine kinase
  galectin 3
  GATA zinc finger domain containing 1
  GIPC PDZ domain containing family member 3
  glucose-6-phosphate isomerase
  glutamic-oxaloacetic transaminase 2
  glutamine amidotransferase like class 1 domain containing 3A
  glutamine rich 1
  glutaredoxin 5
  glutathione peroxidase 4
  glutathione S-transferase mu 3
  glutathione S-transferase pi 1
  glyceraldehyde-3-phosphate dehydrogenase
  glycine cleavage system protein H
  glycogen synthase kinase 3 beta
  glyoxylate and hydroxypyruvate reductase
  growth factor receptor bound protein 2
  H2A clustered histone 21
  H2A.X variant histone
  H2B clustered histone 8
  H4 clustered histone 9
  heat shock protein 90 alpha family class A member 1
  heat shock protein family A (Hsp70) member 9
  heat shock protein family B (small) member 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  hemogen
  heparin binding growth factor
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein H3
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein M
  HEXIM P-TEFb complex subunit 1
  histidine triad nucleotide binding protein 1
  histidine triad nucleotide binding protein 2
  histone deacetylase 1
  histone deacetylase 2
  histone deacetylase 4
  histone deacetylase 6
  huntingtin
  hydroxysteroid 17-beta dehydrogenase 10
  importin 4
  influenza virus NS1A binding protein
  inorganic pyrophosphatase 2
  inosine triphosphatase
  insulin induced gene 2
  integrin subunit alpha 4
  interacts with SUPT6H, CTD assembly factor 1
  interferon regulatory factor 2
  interferon related developmental regulator 2
  ISG15 ubiquitin like modifier
  isochorismatase domain containing 2
  isocitrate dehydrogenase (NADP(+)) 2
  kelch domain containing 3
  keratin 17
  kinesin family member 23
  kinetochore localized astrin (SPAG5) binding protein
  KN motif and ankyrin repeat domains 1
  KRAS proto-oncogene, GTPase
  La ribonucleoprotein 7, transcriptional regulator
  lactamase beta 2
  lactate dehydrogenase A
  lactate dehydrogenase B
  lamin A/C
  LETM1 domain containing 1
  leucine rich repeat containing 42
  leucine rich repeat kinase 2
  LUC7 like 3 pre-mRNA splicing factor
  macrophage migration inhibitory factor
  mannose-6-phosphate receptor, cation dependent
  mediator complex subunit 29
  mediator of DNA damage checkpoint 1
  mercaptopyruvate sulfurtransferase
  metadherin
  methylphosphate capping enzyme
  methyltransferase like 14
  mevalonate kinase
  microcephalin 1
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 5
  mitochondrial fission regulator 1
  mitochondrial ribosomal protein L37
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase kinase 5
  moesin
  MORC family CW-type zinc finger 4
  M-phase phosphoprotein 8
  multiple PDZ domain crumbs cell polarity complex component
  muscleblind like splicing regulator 2
  MYC proto-oncogene, bHLH transcription factor
  myocilin
  myosin IE
  myosin VI
  myosin XVIIIA
  NAD(P)HX dehydratase
  NADH:ubiquinone oxidoreductase subunit AB1
  netrin 4
  neudesin neurotrophic factor
  neurotrophic receptor tyrosine kinase 1
  NGFI-A binding protein 1
  nipsnap homolog 1
  nitric oxide synthase 2
  nitrilase family member 2
  NME/NM23 nucleoside diphosphate kinase 2
  NME1-NME2 readthrough
  non-SMC condensin II complex subunit D3
  NOP56 ribonucleoprotein
  NPL4 homolog, ubiquitin recognition factor
  nuclear distribution C, dynein complex regulator
  nuclear factor of activated T cells 3
  nuclear mitotic apparatus protein 1
  nuclear receptor binding SET domain protein 2
  nuclear receptor subfamily 2 group C member 2
  nucleophosmin 1
  nucleoporin 205
  nucleosome assembly protein 1 like 4
  obscurin like cytoskeletal adaptor 1
  oxoglutarate dehydrogenase
  oxysterol binding protein like 3
  palmitoyl-protein thioesterase 1
  parkin RBR E3 ubiquitin protein ligase
  Parkinsonism associated deglycase
  penta-EF-hand domain containing 1
  peptidase, mitochondrial processing subunit beta
  peptidylprolyl isomerase A
  peptidylprolyl isomerase B
  peripheral myelin protein 2
  peroxiredoxin 4
  peroxiredoxin 5
  peroxiredoxin 6
  phenylalanyl-tRNA synthetase 2, mitochondrial
  phosphatidylinositol transfer protein beta
  phosphoglucomutase 1
  phosphoglycerate kinase 1
  phosphoglycerate kinase 2
  phosphoglycerate mutase 1
  PIH1 domain containing 1
  plasminogen
  pleckstrin homology domain containing A4
  pogo transposable element derived with ZNF domain
  PPFIA binding protein 1
  pre-mRNA processing factor 19
  pre-mRNA processing factor 8
  programmed cell death 6 interacting protein
  prohibitin
  proliferating cell nuclear antigen
  prolyl 4-hydroxylase subunit beta
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, non-ATPase 14
  protein O-fucosyltransferase 1
  protein phosphatase 5 catalytic subunit
  protein tyrosine phosphatase non-receptor type 9
  protein-L-isoaspartate (D-aspartate) O-methyltransferase
  pseudouridine synthase 7
  PTEN induced kinase 1
  purine nucleoside phosphorylase
  pyruvate dehydrogenase phosphatase regulatory subunit
  pyruvate dehyrogenase phosphatase catalytic subunit 1
  RAB11 family interacting protein 5
  RAB34, member RAS oncogene family
  RAD52 homolog, DNA repair protein
  radixin
  Rap guanine nucleotide exchange factor 6
  ras homolog family member F, filopodia associated
  RecQ like helicase 4
  regulatory associated protein of MTOR complex 1
  reticulocalbin 1
  ring finger protein 10
  ring finger protein 4
  ring-box 1
  RIO kinase 1
  RNA binding motif protein 25
  RNA binding motif single stranded interacting protein 2
  RNA polymerase I subunit A
  scavenger receptor class A member 3
  serine and arginine rich splicing factor 7
  serine/threonine kinase 10
  SH3 domain containing kinase binding protein 1
  small nuclear ribonucleoprotein U11/U12 subunit 25
  small ubiquitin like modifier 2
  small ubiquitin like modifier 3
  small ubiquitin like modifier 4
  solute carrier family 25 member 1
  solute carrier family 25 member 39
  solute carrier family 9 member A1
  sorcin
  splicing factor 3a subunit 1
  SPT5 homolog, DSIF elongation factor subunit
  SRC proto-oncogene, non-receptor tyrosine kinase
  SR-related CTD associated factor 8
  staufen double-stranded RNA binding protein 1
  STIP1 homology and U-box containing protein 1
  striatin interacting protein 1
  SUMO specific peptidase 2
  superoxide dismutase 1
  SUZ RNA binding domain containing 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
  synaptotagmin 12
  syntaxin 2
  syntaxin 6
  TAR DNA binding protein
  TATA-box binding protein associated factor 15
  taxilin gamma
  telomerase reverse transcriptase
  tensin 3
  tet methylcytosine dioxygenase 2
  thioredoxin
  thioredoxin domain containing 11
  thioredoxin domain containing 12
  thioredoxin domain containing 16
  THO complex 7
  thyroid hormone receptor alpha
  trafficking protein particle complex 2
  transaldolase 1
  transcription factor CP2
  transgelin
  transgelin 2
  transgelin 3
  transketolase
  translocase of outer mitochondrial membrane 40 like
  triosephosphate isomerase 1
  tripartite motif containing 14
  tripartite motif containing 25
  tripartite motif containing 44
  tubulin folding cofactor A
  tumor protein p53 binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  tyrosyl-tRNA synthetase 1
  ubiquilin 2
  ubiquitin associated protein 1
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L1
  ubiquitin C-terminal hydrolase L3
  UPF2 regulator of nonsense mediated mRNA decay
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  VPS26, retromer complex component B
  VPS35 retromer complex component
  WD repeat domain 1
  WD repeat domain 81
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  X-ray repair cross complementing 6
  Yes1 associated transcriptional regulator
  zinc finger and BTB domain containing 2
  zinc finger CCCH-type containing 7A
  zinc finger NFX1-type containing 1
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.