FUS, FUS RNA binding protein

FUS, FUS RNA binding protein

• This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]

• Gene Synonyms (ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS, RNA-binding protein FUS, 75 kDa DNA-pairing protein, fus-like protein, fused in sarcoma, fusion gene in myxoid liposarcoma, heterogeneous nuclear ribonucleoprotein P2, oncogene FUS, oncogene TLS, translocated in liposarcoma protein,)
• NCBI Gene ID: 2521
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P35637
  UNIPROT ID#>>Q6IBQ5
  UNIPROT ID#>>Q13344
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

FUS RNA binding protein interacts with:

• 5'-3' exoribonuclease 2
  AAR2 splicing factor
  aarF domain containing kinase 5
  A-kinase anchoring protein 8
  angiomotin
  anterior gradient 2, protein disulphide isomerase family member
  apoptotic chromatin condensation inducer 1
  aquarius intron-binding spliceosomal factor
  ariadne RBR E3 ubiquitin protein ligase 2
  armadillo repeat containing 1
  armadillo repeat containing 6
  ataxin 1 like
  ataxin 2 like
  ATP binding cassette subfamily F member 2
  AT-rich interaction domain 1A
  AT-rich interaction domain 2
  aurora kinase A
  autophagy related 16 like 1
  BCL2 associated transcription factor 1
  calcium homeostasis endoplasmic reticulum protein
  cap methyltransferase 1
  cell cycle and apoptosis regulator 2
  cell cycle associated protein 1
  cell division cycle 73
  cell division cycle and apoptosis regulator 1
  centrosomal protein 112
  centrosomal protein 78
  cereblon
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chromosome 2 open reading frame 49
  cilia and flagella associated protein 300
  cleavage and polyadenylation specific factor 6
  coiled-coil domain containing 15
  coiled-coil domain containing 88A
  collagen type XVIII alpha 1 chain
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  CTD small phosphatase like 2
  CTR9 homolog, Paf1/RNA polymerase II complex component
  cullin 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin Q
  cytoskeleton associated protein 4
  DBF4 zinc finger B
  DEAD-box helicase 17
  DEAD-box helicase 20
  DEAD-box helicase 23
  DEAD-box helicase 42
  DEAH-box helicase 40
  defective in cullin neddylation 1 domain containing 1
  DExD-box helicase 21
  DGCR8 microprocessor complex subunit
  DnaJ heat shock protein family (Hsp40) member C10
  DnaJ heat shock protein family (Hsp40) member C7
  dynein light chain Tctex-type 1
  EBNA1 binding protein 2
  elongation factor Tu GTP binding domain containing 2
  elongin C
  endoplasmic reticulum protein 44
  ER membrane protein complex subunit 2
  Era like 12S mitochondrial rRNA chaperone 1
  eukaryotic translation initiation factor 4A3
  eukaryotic translation initiation factor 4H
  eukaryotic translation initiation factor 6
  exosome component 10
  FA complementation group M
  family with sequence similarity 120A
  family with sequence similarity 71 member F1
  family with sequence similarity 98 member A
  F-box and WD repeat domain containing 11
  FUS RNA binding protein
  G protein nucleolar 3
  G protein-coupled receptor 101
  gem nuclear organelle associated protein 4
  gem nuclear organelle associated protein 5
  gem nuclear organelle associated protein 6
  GEN1 Holliday junction 5' flap endonuclease
  glucose-6-phosphate isomerase
  glutamate dehydrogenase 1
  glutamate ionotropic receptor NMDA type subunit 1
  glutamate ionotropic receptor NMDA type subunit 2D
  glutamic-oxaloacetic transaminase 2
  glutathione S-transferase pi 1
  glyceraldehyde-3-phosphate dehydrogenase
  GNAS complex locus
  golgi integral membrane protein 4
  G-patch domain containing 8
  growth factor receptor bound protein 2
  Gse1 coiled-coil protein
  GTPase, IMAP family member 8
  H1.2 linker histone, cluster member
  H2B clustered histone 21
  H3.3 histone A
  H3.3 histone B
  H4 clustered histone 1
  H4 histone 16
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heat shock protein family B (small) member 1
  heat shock protein family D (Hsp60) member 1
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A/B
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein C
  heterogeneous nuclear ribonucleoprotein C like 1
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein H3
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein L
  heterogeneous nuclear ribonucleoprotein M
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U
  heterogeneous nuclear ribonucleoprotein U like 1
  heterogeneous nuclear ribonucleoprotein U like 2
  HEXIM P-TEFb complex subunit 1
  histidyl-tRNA synthetase 2, mitochondrial
  histone deacetylase 2
  histone deacetylase 6
  HIVEP zinc finger 3
  hypoxanthine phosphoribosyltransferase 1
  IL2 inducible T cell kinase
  insulin like growth factor 2 mRNA binding protein 3
  integrator complex subunit 12
  integrator complex subunit 4
  integrator complex subunit 6
  integrin alpha FG-GAP repeat containing 1
  integrin subunit alpha 4
  interleukin 7 receptor
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  karyopherin subunit alpha 2
  karyopherin subunit beta 1
  kelch like family member 40
  kelch like family member 5
  KH RNA binding domain containing, signal transduction associated 1
  KH RNA binding domain containing, signal transduction associated 3
  kinesin family member 22
  kynurenine aminotransferase 3
  La ribonucleoprotein 1, translational regulator
  La ribonucleoprotein 7, transcriptional regulator
  lactate dehydrogenase A
  lactate dehydrogenase B
  lamin A/C
  leucine rich repeats and IQ motif containing 4
  leucine zipper protein 4
  leucyl-tRNA synthetase 1
  LSM12 homolog
  lysozyme
  malate dehydrogenase 1
  malate dehydrogenase 2
  matrin 3
  mediator of DNA damage checkpoint 1
  methionine adenosyltransferase 2A
  methyl-CpG binding domain protein 3
  methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
  methylphosphate capping enzyme
  methylthioadenosine phosphorylase
  methyltransferase like 14
  methyltransferase like 3
  microtubule associated protein tau
  milk fat globule EGF and factor V/VIII domain containing
  minichromosome maintenance complex component 2
  mitochondrial ribosomal protein S18B
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase kinase kinase 3
  Mov10 RISC complex RNA helicase
  Mtr4 exosome RNA helicase
  MTSS I-BAR domain containing 2
  MYC associated factor X
  MYC proto-oncogene, bHLH transcription factor
  myocyte enhancer factor 2D
  myosin heavy chain 10
  NAD(P) dependent steroid dehydrogenase-like
  N-alpha-acetyltransferase 50, NatE catalytic subunit
  NEDD8 ubiquitin like modifier
  neurotrophic receptor tyrosine kinase 1
  NK2 homeobox 1
  NKD inhibitor of WNT signaling pathway 2
  non-POU domain containing octamer binding
  non-SMC condensin II complex subunit G2
  NPL4 homolog, ubiquitin recognition factor
  nuclear cap binding protein subunit 1
  nuclear mitotic apparatus protein 1
  nuclear protein 1, transcriptional regulator
  nuclear receptor coactivator 6
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  nucleophosmin 1
  nucleosome assembly protein 1 like 1
  nudix hydrolase 21
  obscurin like cytoskeletal adaptor 1
  ornithine aminotransferase
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  PAF1 homolog, Paf1/RNA polymerase II complex component
  palmitoyl-protein thioesterase 1
  paraspeckle component 1
  parkin RBR E3 ubiquitin protein ligase
  PDS5 cohesin associated factor A
  peptidase M20 domain containing 2
  peptidylprolyl isomerase A
  peptidylprolyl isomerase E
  peptidylprolyl isomerase like 4
  pericentriolar material 1
  peroxiredoxin 1
  PHD finger protein 10
  phosphatidylinositol binding clathrin assembly protein
  phosphofructokinase, liver type
  phosphofructokinase, platelet
  phosphoglucomutase 1
  phosphoglycerate dehydrogenase
  phosphoglycerate kinase 1
  phosphoinositide-3-kinase regulatory subunit 2
  phospholipase C epsilon 1
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  PIH1 domain containing 1
  pinin, desmosome associated protein
  pleckstrin homology domain containing A4
  pleiotropic regulator 1
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  poly(A) binding protein nuclear 1
  poly(rC) binding protein 1
  poly(rC) binding protein 2
  polybromo 1
  polypyrimidine tract binding protein 1
  polypyrimidine tract binding protein 2
  potassium channel tetramerization domain containing 6
  pre-mRNA processing factor 19
  pre-mRNA processing factor 6
  profilin 1
  prohibitin
  proliferating cell nuclear antigen
  proliferation-associated 2G4
  proline and serine rich coiled-coil 1
  proline rich coiled-coil 2A
  proteasome 20S subunit beta 7
  proteasome 26S subunit, non-ATPase 12
  protein arginine methyltransferase 1
  protein arginine methyltransferase 5
  protein arginine methyltransferase 8
  protein disulfide isomerase family A member 3
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 1 regulatory subunit 10
  PTEN induced kinase 1
  PTPRF interacting protein alpha 1
  purine rich element binding protein B
  pyrroline-5-carboxylate reductase 1
  pyrroline-5-carboxylate reductase 3
  pyruvate kinase M1/2
  RAB7A, member RAS oncogene family
  RAD54 homolog B
  RALY heterogeneous nuclear ribonucleoprotein
  RAN, member RAS oncogene family
  RB binding protein 4, chromatin remodeling factor
  RecQ like helicase 4
  RELA proto-oncogene, NF-kB subunit
  replication protein A1
  replication protein A2
  replication protein A3
  retinoid X receptor alpha
  Rho guanine nucleotide exchange factor 28
  ribonucleoprotein, PTB binding 1
  ribophorin II
  ribosomal protein L11
  ribosomal protein L12
  ribosomal protein L14
  ribosomal protein L18
  ribosomal protein L4
  ribosomal protein L9
  ribosomal protein lateral stalk subunit P1
  ribosomal protein S14
  ribosomal protein S27
  ribosomal protein S5
  ribosomal protein S6 kinase B2
  ribosomal protein S8
  ribosomal protein S9
  ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring-box 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 10
  RNA binding motif protein 14
  RNA binding motif protein 17
  RNA binding motif protein 25
  RNA binding motif protein 39
  RNA binding motif protein 7
  RNA binding motif protein X-linked
  RNA polymerase II subunit A
  RNA polymerase II subunit B
  RNA transcription, translation and transport factor
  SAFB like transcription modulator
  salt inducible kinase 2
  SAP domain containing ribonucleoprotein
  SAP30 binding protein
  scaffold attachment factor B
  scaffold attachment factor B2
  SEC13 homolog, nuclear pore and COPII coat complex component
  sequestosome 1
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 1
  serine and arginine rich splicing factor 10
  serine and arginine rich splicing factor 2
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 4
  serine and arginine rich splicing factor 5
  serine and arginine rich splicing factor 6
  serine and arginine rich splicing factor 7
  serine and arginine rich splicing factor 9
  serine/threonine kinase receptor associated protein
  SERPINE1 mRNA binding protein 1
  serrate, RNA effector molecule
  Shoc2, leucine rich repeat scaffold protein
  single stranded DNA binding protein 1
  single-pass membrane protein with coiled-coil domains 3
  sirtuin 7
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein D3 polypeptide
  small nuclear ribonucleoprotein polypeptide A
  small nuclear ribonucleoprotein polypeptide C
  small nuclear ribonucleoprotein polypeptides B and B1
  small nuclear ribonucleoprotein U1 subunit 70
  small nuclear ribonucleoprotein U5 subunit 200
  SMU1 DNA replication regulator and spliceosomal factor
  SNW domain containing 1
  solute carrier family 1 member 5
  solute carrier family 22 member 11
  solute carrier family 25 member 3
  spermatid perinuclear RNA binding protein
  spermatogenesis associated 6
  Spi-1 proto-oncogene
  splicing factor 1
  splicing factor 3a subunit 1
  splicing factor 3a subunit 2
  splicing factor 3a subunit 3
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  splicing factor 3b subunit 3
  splicing factor 3b subunit 4
  splicing factor proline and glutamine rich
  SRSF protein kinase 1
  SRY-box transcription factor 2
  SS18 subunit of BAF chromatin remodeling complex
  ST13 Hsp70 interacting protein
  statherin
  SUMO1 activating enzyme subunit 1
  suppressor of variegation 3-9 homolog 1
  survival of motor neuron 1, telomeric
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  TAR DNA binding protein
  target of EGR1, exonuclease
  TATA-box binding protein associated factor 15
  TATA-box binding protein like 1
  taxilin alpha
  t-complex 1
  TELO2 interacting protein 2
  thioredoxin like 4B
  THO complex 1
  THO complex 2
  THO complex 5
  threonyl-tRNA synthetase 1
  thymocyte selection associated high mobility group box
  thyroid hormone receptor alpha
  thyroid hormone receptor associated protein 3
  thyroid hormone receptor interactor 4
  TNF receptor associated factor 6
  TNFAIP3 interacting protein 1
  TOX high mobility group box family member 4
  transcription factor 7 like 2
  transformer 2 alpha homolog
  transformer 2 beta homolog
  transient receptor potential cation channel subfamily M member 4
  transketolase
  translocase of inner mitochondrial membrane 50
  translocase of outer mitochondrial membrane 34
  tripartite motif containing 25
  tripartite motif containing 28
  Tu translation elongation factor, mitochondrial
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin beta class I
  tudor domain containing 3
  tumor necrosis factor
  tumor protein p53 binding protein 1
  tumor protein p63
  tumor protein p73
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  U2 snRNP associated SURP domain containing
  ubiquilin 2
  ubiquitin associated protein 2
  ubiquitin associated protein 2 like
  ubiquitin C
  ubiquitin conjugating enzyme E2 I
  ubiquitin like 4A
  ubiquitin like modifier activating enzyme 1
  ubiquitin recognition factor in ER associated degradation 1
  UFM1 specific ligase 1
  UPF1 RNA helicase and ATPase
  UPF2 regulator of nonsense mediated mRNA decay
  UPF3A regulator of nonsense mediated mRNA decay
  upstream transcription factor 2, c-fos interacting
  uveal autoantigen with coiled-coil domains and ankyrin repeats
  valosin containing protein
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  WD repeat domain 77
  WD repeat domain 82
  WW domain binding protein 4
  WW domain containing oxidoreductase
  XPA binding protein 2
  X-ray repair cross complementing 6
  Y-box binding protein 1
  Y-box binding protein 3
  YEATS domain containing 4
  Yes1 associated transcriptional regulator
  yippee like 1
  zinc finger CCCH-type containing 18
  zinc finger CCCH-type containing, antiviral 1
  zinc finger CCHC-type containing 8
  zinc finger FYVE-type containing 21
  zinc finger MYM-type containing 2
  zinc finger protein 326
  zinc finger RNA binding protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.