CFL1, cofilin 1

CFL1, cofilin 1

• The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

• Gene Synonyms (cofilin-1, 18 kDa phosphoprotein, cofilin 1 (non-muscle), cofilin, non-muscle isoform, epididymis secretory protein Li 15, p18, CFL, HEL-S-15, cofilin,)
• NCBI Gene ID: 1072
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P23528
  UNIPROT ID#>>V9HWI5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cofilin 1 interacts with:

• AAR2 splicing factor
  acetyl-CoA acyltransferase 2
  actin beta like 2
  actin related protein 2
  activating transcription factor 2
  acyl-CoA thioesterase 1
  adenylate kinase 3
  aldehyde dehydrogenase 4 family member A1
  aldo-keto reductase family 1 member A1
  anillin actin binding protein
  anterior gradient 2, protein disulphide isomerase family member
  ataxin 1
  ataxin 3
  calmodulin-like 3
  catenin beta 1
  CDC28 protein kinase regulatory subunit 2
  cell division cycle 73
  CF transmembrane conductance regulator
  chloride voltage-gated channel 5
  coactosin like F-actin binding protein 1
  cofilin 2
  coronin, actin binding protein 1C
  cullin 7
  cyclase associated actin cytoskeleton regulatory protein 1
  cyclase associated actin cytoskeleton regulatory protein 2
  CYLD lysine 63 deubiquitinase
  cysteine and glycine rich protein 1
  cysteine rich protein 1
  cysteinyl-tRNA synthetase 2, mitochondrial
  cytochrome c oxidase copper chaperone COX17
  DAZ associated protein 1
  DDB1 and CUL4 associated factor 4 like 2
  deoxyuridine triphosphatase
  DExD-box helicase 39B
  dishevelled segment polarity protein 2
  drebrin 1
  drebrin like
  dynein light chain LC8-type 1
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  enolase 1
  epidermal growth factor receptor
  epithelial cell transforming 2
  estrogen receptor 1
  estrogen receptor 2
  eukaryotic translation initiation factor 4B
  eukaryotic translation initiation factor 6
  FA complementation group D2
  F-box protein 25
  F-box protein 7
  fibronectin 1
  filamin A
  fission, mitochondrial 1
  fumarylacetoacetate hydrolase domain containing 1
  fumarylacetoacetate hydrolase domain containing 2A
  FUS RNA binding protein
  G protein-coupled receptor kinase 5
  G3BP stress granule assembly factor 1
  glutamic-oxaloacetic transaminase 2
  glutamic--pyruvic transaminase
  glutamic--pyruvic transaminase 2
  glyceraldehyde-3-phosphate dehydrogenase
  H2A.X variant histone
  heat shock protein family A (Hsp70) member 9
  heat shock protein family E (Hsp10) member 1
  heat shock protein family H (Hsp110) member 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  heterogeneous nuclear ribonucleoprotein A1
  HEXIM P-TEFb complex subunit 1
  immunoglobulin superfamily member 8
  integrin subunit alpha 4
  IQ motif containing GTPase activating protein 1
  ISG15 ubiquitin like modifier
  isochorismatase domain containing 2
  Jupiter microtubule associated homolog 1
  keratin 17
  KRAS proto-oncogene, GTPase
  kynureninase
  La ribonucleoprotein 7, transcriptional regulator
  lactate dehydrogenase A
  lactate dehydrogenase A like 6A
  lactate dehydrogenase B
  leucine rich repeat kinase 2
  LIM domain and actin binding 1
  LIM domain and actin binding 1
  LIM domain kinase 1
  LIM domain kinase 2
  lysophospholipase 2
  malate dehydrogenase 2
  methylphosphate capping enzyme
  methylthioadenosine phosphorylase
  methyltransferase like 14
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 5
  mitogen-activated protein kinase 6
  mitogen-activated protein kinase 8 interacting protein 2
  MYC binding protein
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 9
  myosin IC
  myosin IC
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  neurotrophic receptor tyrosine kinase 1
  Nik related kinase
  NME/NM23 nucleoside diphosphate kinase 1
  NME/NM23 nucleoside diphosphate kinase 2
  NME1-NME2 readthrough
  NPR2 like, GATOR1 complex subunit
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  nucleophosmin 1
  nucleoporin 214
  parkin RBR E3 ubiquitin protein ligase
  Parkinsonism associated deglycase
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  peptidylprolyl isomerase A
  peroxiredoxin 1
  peroxiredoxin 5
  phosphatase and tensin homolog
  phosphatidylethanolamine binding protein 1
  PIH1 domain containing 1
  pirin
  pleckstrin homology domain containing A4
  poly(A) specific ribonuclease subunit PAN2
  poly(rC) binding protein 1
  potassium channel tetramerization domain containing 15
  pre-mRNA processing factor 8
  presenilin 1
  profilin 1
  prohibitin
  prostaglandin reductase 1
  protection of telomeres 1
  protein kinase C zeta
  protein phosphatase 1 catalytic subunit beta
  pseudouridine 5'-phosphatase
  PTEN induced kinase 1
  pyruvate kinase M1/2
  RAB10, member RAS oncogene family
  RAB7A, member RAS oncogene family
  RAD21 cohesin complex component
  RecQ like helicase 4
  reticulon 4
  Rho associated coiled-coil containing protein kinase 1
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase B2
  RNA polymerase I and III subunit C
  SEC14 and spectrin domains 1
  serine/threonine/tyrosine interacting protein
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  slingshot protein phosphatase 1
  slingshot protein phosphatase 2
  slingshot protein phosphatase 3
  SMAD specific E3 ubiquitin protein ligase 1
  solute carrier family 2 member 4
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRY-box transcription factor 2
  sulfiredoxin 1
  superoxide dismutase 1
  superoxide dismutase 2
  synaptopodin
  telomeric repeat binding factor 1
  testin LIM domain protein
  testis associated actin remodelling kinase 1
  testis associated actin remodelling kinase 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  thioredoxin domain containing 17
  thymopoietin
  TNF receptor associated protein 1
  TNFAIP3 interacting protein 2
  transcription factor CP2
  transgelin
  transgelin 2
  transketolase
  transport and golgi organization 2 homolog
  triosephosphate isomerase 1
  tripartite motif containing 15
  tropomodulin 3
  tropomyosin 1, alpha
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin fold modifier 1
  ubiquitin recognition factor in ER associated degradation 1
  ubiquitin specific peptidase 14
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  VRK serine/threonine kinase 3
  WD repeat domain 1
  WW domain containing E3 ubiquitin protein ligase 2
  Yes1 associated transcriptional regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.