HIF1A, hypoxia inducible factor 1 subunit alpha

HIF1A, hypoxia inducible factor 1 subunit alpha

• This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

• Gene Synonyms (hypoxia-inducible factor 1-alpha, ARNT interacting protein, PAS domain-containing protein 8, basic-helix-loop-helix-PAS protein MOP1, class E basic helix-loop-helix protein 78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1 alpha isoform I.3, hypoxia-inducible factor1alpha, member of PAS protein 1, member of PAS superfamily 1, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78,)
• NCBI Gene ID: 3091
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D0VY79
  UNIPROT ID#>>Q16665
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hypoxia inducible factor 1 subunit alpha interacts with:

• 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
  actin related protein 2
  apoptosis inducing factor mitochondria associated 1
  aryl hydrocarbon receptor nuclear translocator
  aryl hydrocarbon receptor nuclear translocator 2
  aryl hydrocarbon receptor nuclear translocator-like
  aryl-hydrocarbon receptor
  ATP binding cassette subfamily F member 2
  ATPase family AAA domain containing 3A
  aurora kinase A
  BAG cochaperone 2
  basic helix-loop-helix family member e41
  B-TFIID TATA-box binding protein associated factor 1
  BTG3 associated nuclear protein
  cAMP responsive element binding protein 3 like 1
  Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
  cell cycle and apoptosis regulator 2
  centrosomal protein 350
  cleavage and polyadenylation specific factor 1
  cleavage factor polyribonucleotide kinase subunit 1
  COBW domain containing 1
  COP9 signalosome subunit 5
  COP9 signalosome subunit 5
  copper metabolism domain containing 1
  CREB binding protein
  cullin 2
  C-X-C motif chemokine receptor 4
  cytoplasmic polyadenylation element binding protein 2
  death associated protein 3
  defective in cullin neddylation 1 domain containing 1
  DExD-box helicase 39A
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  DnaJ heat shock protein family (Hsp40) member A1
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member A3
  DnaJ heat shock protein family (Hsp40) member B1
  DnaJ heat shock protein family (Hsp40) member B6
  dolichyl-phosphate mannosyltransferase subunit 1, catalytic
  dynein axonemal intermediate chain 1
  E1A binding protein p400
  E2F transcription factor 7
  Ecm29 proteasome adaptor and scaffold
  egl-9 family hypoxia inducible factor 1
  egl-9 family hypoxia inducible factor 2
  egl-9 family hypoxia inducible factor 3
  ELL associated factor 2
  elongation factor for RNA polymerase II
  elongation factor Tu GTP binding domain containing 2
  elongator acetyltransferase complex subunit 3
  elongator complex protein 1
  elongin B
  elongin C
  Era like 12S mitochondrial rRNA chaperone 1
  eukaryotic translation initiation factor 5A2
  exportin 1
  exportin 5
  exportin for tRNA
  FA complementation group I
  Fas associated factor 1
  Fas associated factor family member 2
  F-box and WD repeat domain containing 7
  fizzy and cell division cycle 20 related 1
  formimidoyltransferase cyclodeaminase
  G kinase anchoring protein 1
  G protein nucleolar 3
  GCN1 activator of EIF2AK4
  GLIS family zinc finger 2
  glutamyl-tRNA synthetase 2, mitochondrial
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  H4 clustered histone 1
  H4 clustered histone 9
  HEAT repeat containing 1
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein family A (Hsp70) member 1 like
  heat shock protein family A (Hsp70) member 2
  heat shock protein family A (Hsp70) member 4
  heat shock protein family A (Hsp70) member 8
  hepatocyte nuclear factor 4 alpha
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein L
  heterogeneous nuclear ribonucleoprotein M
  HEXIM P-TEFb complex subunit 1
  hexokinase 1
  high mobility group AT-hook 1
  histone deacetylase 3
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 6
  histone deacetylase 7
  hydroxysteroid 17-beta dehydrogenase 12
  hypoxia inducible factor 1 subunit alpha
  hypoxia inducible factor 1 subunit alpha inhibitor
  hypoxia inducible factor 3 subunit alpha
  importin 5
  inhibitor of growth family member 1
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inhibitor of nuclear factor kappa B kinase subunit beta
  intercellular adhesion molecule 1
  interleukin 11
  IQ motif containing GTPase activating protein 1
  IQ motif containing GTPase activating protein 3
  ISG15 ubiquitin like modifier
  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
  Jun proto-oncogene, AP-1 transcription factor subunit
  karyopherin subunit alpha 1
  karyopherin subunit alpha 3
  karyopherin subunit alpha 4
  karyopherin subunit alpha 5
  karyopherin subunit alpha 6
  lactate dehydrogenase A
  large tumor suppressor kinase 2
  leucine rich pentatricopeptide repeat containing
  leucine rich repeat kinase 2
  lysine acetyltransferase 2B
  lysine acetyltransferase 5
  lysine demethylase 3A
  lysine demethylase 4C
  LysM domain containing 2
  lysosomal associated membrane protein 2
  macrophage migration inhibitory factor
  MAF bZIP transcription factor G
  MAF bZIP transcription factor K
  matrin 3
  MCL1 apoptosis regulator, BCL2 family member
  MDM2 proto-oncogene
  mediator complex subunit 12
  mediator complex subunit 13
  mediator complex subunit 13L
  mediator complex subunit 14
  mediator complex subunit 15
  mediator complex subunit 23
  metastasis associated 1
  methyltransferase like 15
  midline 2
  minichromosome maintenance complex component 3
  minichromosome maintenance complex component 7
  mitochondrial contact site and cristae organizing system subunit 13
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase kinase 3
  mitogen-activated protein kinase kinase 5
  MMS19 homolog, cytosolic iron-sulfur assembly component
  MON2 homolog, regulator of endosome-to-Golgi trafficking
  mutS homolog 2
  MYC associated factor X
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 1
  myosin heavy chain 2
  myosin heavy chain 3
  myosin heavy chain 4
  myosin heavy chain 6
  myosin IB
  myosin IXB
  myosin light chain 1
  N(alpha)-acetyltransferase 10, NatA catalytic subunit
  N-alpha-acetyltransferase 10, NatA catalytic subunit
  N-alpha-acetyltransferase 11, NatA catalytic subunit
  necdin, MAGE family member
  NEDD8 ubiquitin like modifier
  nestin
  N-ethylmaleimide sensitive factor, vesicle fusing ATPase
  neurobeachin like 1
  neurofibromin 2
  neurolysin
  nibrin
  NSFL1 cofactor
  nuclear receptor coactivator 1
  nuclear receptor coactivator 2
  nuclear receptor subfamily 4 group A member 1
  nucleoporin 210
  nucleoporin 93
  nucleoside-triphosphatase, cancer-related
  OS9 endoplasmic reticulum lectin
  OTU deubiquitinase 7B
  parkin RBR E3 ubiquitin protein ligase
  patatin like phospholipase domain containing 6
  pelota mRNA surveillance and ribosome rescue factor
  period circadian clock 1
  period circadian regulator 1
  phosphofructokinase, liver type
  phosphofructokinase, muscle
  phosphoglycerate kinase 1
  phospholipase D1
  phospholipase D2
  pleckstrin homology domain containing A5
  poly(rC) binding protein 1
  poly(rC) binding protein 2
  polycomb group ring finger 2
  polypyrimidine tract binding protein 1
  pre-mRNA processing factor 6
  pre-mRNA processing factor 8
  prostaglandin E synthase 3
  proteasome 20S subunit alpha 4
  proteasome 20S subunit alpha 7
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, non-ATPase 10
  protein inhibitor of activated STAT 1
  protein kinase cAMP-activated catalytic subunit alpha
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 2 scaffold subunit Aalpha
  protein tyrosine kinase 6
  pyruvate dehydrogenase kinase 1
  pyruvate dehyrogenase phosphatase catalytic subunit 1
  pyruvate kinase M1/2
  RAB13, member RAS oncogene family
  Rac GTPase activating protein 1
  RAD23 homolog B, nucleotide excision repair protein
  RALY heterogeneous nuclear ribonucleoprotein
  RAR related orphan receptor A
  RB transcriptional corepressor 1
  receptor for activated C kinase 1
  regulatory associated protein of MTOR complex 1
  RELA proto-oncogene, NF-kB subunit
  replication factor C subunit 2
  replication factor C subunit 3
  replication factor C subunit 4
  replication factor C subunit 5
  Rho related BTB domain containing 3
  rhomboid 5 homolog 1
  ring finger protein 4
  ring-box 1
  RNA binding motif protein 38
  RNA polymerase II subunit B
  RNA polymerase mitochondrial
  RPTOR independent companion of MTOR complex 2
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  RWD domain containing 3
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  septin 9
  sequestosome 1
  serine palmitoyltransferase long chain base subunit 1
  serine/threonine kinase 11
  serine/threonine kinase 39
  SET domain containing 7, histone lysine methyltransferase
  SHC adaptor protein 1
  signal transducer and activator of transcription 3
  SIN3 transcription regulator family member A
  sirtuin 1
  sirtuin 2
  SMAD family member 3
  small nuclear ribonucleoprotein U5 subunit 200
  small ubiquitin like modifier 1
  solute carrier family 25 member 22
  Sp1 transcription factor
  spermidine/spermine N1-acetyltransferase 1
  spermidine/spermine N1-acetyltransferase family member 2
  spliceosome associated factor 3, U4/U6 recycling protein
  splicing factor 3b subunit 2
  sprouty RTK signaling antagonist 2
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRP receptor subunit beta
  SSX family member 4
  SSX family member 4B
  STIP1 homology and U-box containing protein 1
  SUMO specific peptidase 3
  SUN domain containing ossification factor
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  TEA domain transcription factor 2
  telomere maintenance 2
  testis specific 10
  tet methylcytosine dioxygenase 1
  tetratricopeptide repeat domain 1
  thioredoxin interacting protein
  thyroid hormone receptor interactor 13
  TNF receptor associated factor 6
  transcription elongation factor A N-terminal and central domain containing 2
  transformation/transcription domain associated protein
  transforming growth factor beta 1
  translocase of inner mitochondrial membrane 50
  transmembrane protein 33
  tripartite motif containing 28
  Tu translation elongation factor, mitochondrial
  tubulin alpha 1a
  tubulin folding cofactor D
  tumor protein p53
  tumor protein p63
  tumor protein p73
  twist family bHLH transcription factor 1
  ubiquitin C
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 I
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 19
  ubiquitin specific peptidase 20
  ubiquitin specific peptidase 28
  ubiquitin specific peptidase 7
  UBX domain protein 1
  UBX domain protein 7
  unc-45 myosin chaperone A
  uridine monophosphate synthetase
  UTP23 small subunit processome component
  uveal autoantigen with coiled-coil domains and ankyrin repeats
  valosin containing protein
  vascular endothelial growth factor A
  vasodilator stimulated phosphoprotein
  VHL like
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  von Willebrand factor A domain containing 8
  WW domain containing oxidoreductase
  WW domain containing transcription regulator 1
  X-ray repair cross complementing 5
  Y-box binding protein 1
  zinc finger CCCH-type containing 12A
  zinc finger protein 197
  zinc finger protein 518A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.