DDX5, DEAD-box helicase 5

DDX5, DEAD-box helicase 5

• This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]

• Gene Synonyms (probable ATP-dependent RNA helicase DDX5, ATP-dependent RNA helicase DDX5, DEAD (Asp-Glu-Ala-Asp) box helicase 5, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5, DEAD box protein 5, DEAD box-5, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD), RNA helicase p68, G17P1, HLR1, HUMP68, p68,)
• NCBI Gene ID: 1655
• Species: Homo sapiens (Human)
• UNIPROT ID#>>J3KTA4
  UNIPROT ID#>>P17844
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DEAD-box helicase 5 interacts with:

• AAR2 splicing factor
  agrin
  A-kinase anchoring protein 8
  anterior gradient 2, protein disulphide isomerase family member
  armadillo repeat containing 8
  ataxin 2
  ataxin 2 like
  aurora kinase A
  aurora kinase B
  BCL2-associated athanogene 2
  breast carcinoma amplified sequence 2
  bromodomain containing 7
  cap methyltransferase 1
  CCCTC-binding factor
  CD2 cytoplasmic tail binding protein 2
  CDK5 regulatory subunit associated protein 2
  cell division cycle 37, HSP90 cochaperone
  centrosomal protein 250
  cereblon
  chromobox 7
  cleavage and polyadenylation specific factor 6
  coiled-coil domain containing 8
  contactin associated protein 1
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  cullin 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin-dependent kinase 1
  DEAD-box helicase 17
  DEAD-box helicase 18
  DEAD-box helicase 5
  DEAH-box helicase 15
  DEAH-box helicase 36
  DEAH-box helicase 38
  defective in cullin neddylation 1 domain containing 1
  derlin 1
  DExH-box helicase 9
  DGCR8 microprocessor complex subunit
  DNA polymerase delta 1, catalytic subunit
  DnaJ heat shock protein family (Hsp40) member C2
  double PHD fingers 2
  drebrin like
  drosha ribonuclease III
  E1A binding protein p300
  elaC ribonuclease Z 2
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  endoplasmic reticulum oxidoreductase 1 alpha
  enhancer of mRNA decapping 4
  enhancer of zeste 2 polycomb repressive complex 2 subunit
  epidermal growth factor receptor
  ERCC excision repair 6, chromatin remodeling factor
  estrogen receptor 1
  ETS transcription factor ERG
  eukaryotic translation elongation factor 2
  eukaryotic translation initiation factor 2A
  eukaryotic translation initiation factor 4A3
  EWS RNA binding protein 1
  exportin 1
  expressed sequence AI837181
  FA complementation group D2
  Fas associated factor 1
  F-box and WD repeat domain containing 4
  F-box protein 46
  F-box protein 6
  F-box protein 7
  fibrillarin
  fibroblast growth factor receptor substrate 3
  fibronectin 1
  FKBP prolyl isomerase 10
  FUS RNA binding protein
  fused in sarcoma
  glutamyl-prolyl-tRNA synthetase 1
  glycogen synthase kinase 3 alpha
  glycogen synthase kinase 3 beta
  golgi integral membrane protein 4
  GTP binding protein 4
  guanine monophosphate synthase
  H4 clustered histone 1
  heparin binding growth factor
  hes related family bHLH transcription factor with YRPW motif 1
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein H2
  heterogeneous nuclear ribonucleoprotein H3
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein M
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 1
  histone deacetylase 2
  histone deacetylase 3
  immunoglobulin superfamily member 8
  importin 11
  INO80 complex subunit B
  inosine monophosphate dehydrogenase 1
  inositol polyphosphate phosphatase like 1
  insulin like growth factor 2 mRNA binding protein 3
  integrin alpha FG-GAP repeat containing 1
  integrin linked kinase
  integrin subunit alpha 4
  interleukin 7 receptor
  IQ motif containing GTPase activating protein 1
  KH RNA binding domain containing, signal transduction associated 1
  KH RNA binding domain containing, signal transduction associated 2
  Kin17 DNA and RNA binding protein
  kinase suppressor of ras 1
  La ribonucleoprotein 7, transcriptional regulator
  lamin A/C
  leucine rich repeat and sterile alpha motif containing 1
  leucine zipper protein 4
  LUC7 like 2, pre-mRNA splicing factor
  macrophage erythroblast attacher, E3 ubiquitin ligase
  MAGE family member A3
  MAPK activated protein kinase 2
  matrin 3
  MDM2 proto-oncogene
  mediator complex subunit 12
  metal regulatory transcription factor 1
  methyl-CpG binding domain protein 3
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 3
  microtubule associated protein 1 light chain 3 alpha
  microtubule associated serine/threonine kinase 3
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 5
  minichromosome maintenance complex component 7
  mitochondrial carrier 2
  mitogen-activated protein kinase 10
  mitogen-activated protein kinase kinase 3
  Mtr4 exosome RNA helicase
  muscleblind like splicing regulator 1
  MYC proto-oncogene, bHLH transcription factor
  myogenic differentiation 1
  nascent polypeptide associated complex subunit alpha
  NEDD8 ubiquitin like modifier
  neurotrophic receptor tyrosine kinase 1
  nibrin
  N-myc downstream regulated 1
  nuclear receptor subfamily 2 group C member 2
  nuclear receptor subfamily 2 group E member 1
  nuclear RNA export factor 1
  nuclear transcription factor, X-box binding 1
  O-6-methylguanine-DNA methyltransferase
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  parkin RBR E3 ubiquitin protein ligase
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  peptidylprolyl isomerase E
  PHD finger protein 1
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphoribosyl pyrophosphate synthetase associated protein 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 4
  poly(rC) binding protein 1
  potassium channel tetramerization domain containing 10
  pre-mRNA processing factor 19
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 8
  prohibitin
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, non-ATPase 14
  proteasome activator subunit 3
  protein inhibitor of activated STAT 1
  protein kinase C alpha
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit gamma
  PTEN induced kinase 1
  RAN binding protein 9
  RecQ like helicase 4
  replication protein A1
  replication protein A2
  replication protein A3
  required for meiotic nuclear division 5 homolog A
  ribosomal protein L10
  ribosomal protein L19
  ribosomal protein S16
  ribosomal protein S20
  ribosomal protein S6 kinase B2
  ring finger protein 123
  ring finger protein 2
  ring finger protein 4
  RING1 and YY1 binding protein
  ring-box 1
  RIO kinase 1
  RNA binding fox-1 homolog 2
  RNA binding motif protein 10
  RNA binding motif protein 4
  RNA binding motif protein X-linked
  RNA polymerase II subunit A
  RNA transcription, translation and transport factor
  SBDS ribosome maturation factor
  sequestosome 1
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 1
  serine protease 1
  serine/arginine repetitive matrix 2
  serine/threonine kinase 24
  serum/glucocorticoid regulated kinase 2
  SET domain containing 1A, histone lysine methyltransferase
  SHC adaptor protein 1
  signal recognition particle 14
  SKI proto-oncogene
  SMAD family member 3
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein polypeptide A'
  small nuclear ribonucleoprotein polypeptide C
  small nuclear ribonucleoprotein U1 subunit 70
  snail family transcriptional repressor 1
  SNW domain containing 1
  Sp1 transcription factor
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  splicing factor 3a subunit 1
  splicing factor 3a subunit 2
  splicing factor 3b subunit 3
  SprT-like N-terminal domain
  SRSF protein kinase 1
  SRY-box transcription factor 2
  staufen double-stranded RNA binding protein 1
  stratifin
  survival of motor neuron 1, telomeric
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  synapsin I
  synaptotagmin binding cytoplasmic RNA interacting protein
  TAR DNA binding protein
  TATA-box binding protein
  TATA-box binding protein associated factor 15
  thymopoietin
  thyroid hormone receptor associated protein 3
  thyroid hormone receptor interactor 4
  TNFAIP3 interacting protein 2
  transcription elongation factor A1
  transcription factor CP2
  transcriptional adaptor 2A
  transforming growth factor beta 1
  tripartite motif containing 25
  tripartite motif containing 28
  tRNA methyltransferase 6
  troponin T1, slow skeletal type
  tubulin gamma complex associated protein 3
  tumor necrosis factor
  tumor protein p53
  tyrosine kinase 2
  tyrosine kinase non receptor 1
  U2 small nuclear RNA auxiliary factor 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 I
  ubiquitin C-terminal hydrolase L3
  ubiquitin specific peptidase 14
  unk zinc finger
  UPF1 RNA helicase and ATPase
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  vitronectin
  von Hippel-Lindau tumor suppressor
  VRK serine/threonine kinase 1
  WD repeat domain 4
  WD repeat domain 77
  WT1 associated protein
  WW domain binding protein 11
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 4
  X-ray repair cross complementing 6
  Y box protein 1
  Yes1 associated transcriptional regulator
  yippee like 5
  YY1 transcription factor
  zinc finger FYVE-type containing 21
  zinc finger protein 217
  ZW10 interacting kinetochore protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.