EEF1A1, eukaryotic translation elongation factor 1 alpha 1

EEF1A1, eukaryotic translation elongation factor 1 alpha 1

• This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, LENG7, PTI1, eEF1A-1, elongation factor 1-alpha 1, CTCL tumor antigen, EF-1-alpha-1, EF1a-like protein, cervical cancer suppressor 3, elongation factor 1 alpha subunit, elongation factor Tu, epididymis secretory sperm binding protein, eukaryotic elongation factor 1 A-1, eukaryotic translation elongation factor 1 alpha 1-like 14, glucocorticoid receptor AF-1 specific elongation factor, leukocyte receptor cluster (LRC) member 7, leukocyte receptor cluster member 7, prostate tumor-inducing protein 1, translation elongation factor 1 alpha 1-like 14,)
• NCBI Gene ID: 1915
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P68104
  UNIPROT ID#>>Q6IPS9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation elongation factor 1 alpha 1 interacts with:

• 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  5'-3' exoribonuclease 2
  activation induced cytidine deaminase
  activator of HSP90 ATPase activity 1
  AHNAK nucleoprotein
  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  ankyrin repeat and BTB domain containing 2
  ankyrin repeat domain 24
  anterior gradient 2, protein disulphide isomerase family member
  arginine and serine rich coiled-coil 1
  argonaute RISC catalytic component 3
  ariadne RBR E3 ubiquitin protein ligase 2
  ATP binding cassette subfamily C member 1
  aurora kinase A
  axin 1
  BRMS1 transcriptional repressor and anoikis regulator
  bromodomain containing 7
  BTB domain containing 2
  CASP2 and RIPK1 domain containing adaptor with death domain
  C-C motif chemokine ligand 18
  C-C motif chemokine ligand 22
  cell cycle and apoptosis regulator 2
  cell division cycle 37, HSP90 cochaperone
  cell division cycle 73
  centrosomal protein 250
  coiled-coil domain containing 130
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  cullin 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cysteine rich C-terminal 1
  cytochrome c oxidase copper chaperone COX17
  DEAD-box helicase 17
  defective in cullin neddylation 1 domain containing 1
  diablo IAP-binding mitochondrial protein
  DNA ligase 4
  DNA polymerase epsilon 2, accessory subunit
  dynein light chain LC8-type 1
  E1A binding protein p300
  Ecm29 proteasome adaptor and scaffold
  EEF1A lysine methyltransferase 1
  elongation factor Tu GTP binding domain containing 2
  enolase 2
  enolase 3
  epidermal growth factor receptor
  estrogen receptor 2
  estrogen related receptor beta
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 alpha 2
  eukaryotic translation elongation factor 1 beta 2
  eukaryotic translation elongation factor 1 delta
  eukaryotic translation elongation factor 1 gamma
  eukaryotic translation elongation factor 2
  eukaryotic translation initiation factor 3 subunit F
  eukaryotic translation initiation factor 4A1
  eukaryotic translation initiation factor 4A3
  exosome component 4
  exportin 5
  family with sequence similarity 98 member B
  Fas associated factor 1
  F-box protein 6
  fibrillarin
  fibronectin 1
  four and a half LIM domains 2
  FUS RNA binding protein
  G protein-coupled receptor kinase 5
  GDP-L-fucose synthase
  GDP-mannose pyrophosphorylase B
  general transcription factor IIi
  glutathione peroxidase 7
  glyceraldehyde-3-phosphate dehydrogenase
  glycogen synthase kinase 3 beta
  golgi reassembly stacking protein 2
  growth arrest and DNA damage inducible gamma
  H2A clustered histone 7
  H2A.X variant histone
  H3 clustered histone 6
  heat shock protein 90 alpha family class A member 1
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 2
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heat shock protein family B (small) member 1
  heat shock protein family B (small) member 2
  heat shock protein family E (Hsp10) member 1
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein L
  heterogeneous nuclear ribonucleoprotein U like 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 2
  histone deacetylase 4
  histone deacetylase 6
  HtrA serine peptidase 2
  huntingtin interacting protein K
  hydroxysteroid 17-beta dehydrogenase 10
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inner membrane mitochondrial protein
  inositol polyphosphate phosphatase like 1
  insulin like growth factor 1 receptor
  integrin alpha FG-GAP repeat containing 1
  integrin subunit alpha 4
  integrin subunit beta 1 binding protein 1
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  intersectin 1
  IQ motif containing B1
  junction plakoglobin
  keratin 17
  kinase suppressor of ras 1
  kinesin family member 1B
  KRAS proto-oncogene, GTPase
  La ribonucleoprotein 7, transcriptional regulator
  laminin subunit alpha 4
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
  leucine rich repeat containing G protein-coupled receptor 4
  leucine rich repeat kinase 2
  leucyl-tRNA synthetase 1
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  lysine methyltransferase 5C
  MAD2L1 binding protein
  MAGE family member A1
  MAGE family member A3
  MAGE family member D2
  mago homolog, exon junction complex subunit
  MDM2 proto-oncogene
  membrane metalloendopeptidase
  metal regulatory transcription factor 1
  methionine adenosyltransferase 1A
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 3
  mex-3 RNA binding family member C
  midline 1
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 5
  mitochondrial ribosomal protein L14
  mitochondrial ribosomal protein L42
  mitochondrial ribosomal protein S7
  mitochondrial rRNA methyltransferase 1
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase kinase kinase 14
  MLLT3 super elongation complex subunit
  MNAT1 component of CDK activating kinase
  Mov10 RISC complex RNA helicase
  MT-RNR2 like 1
  MYB binding protein 1a
  Myb like, SWIRM and MPN domains 1
  myocilin
  NEDD8 ubiquitin like modifier
  neuraminidase 1
  neuroligin 3
  neuronal regeneration related protein
  neurotrophic receptor tyrosine kinase 1
  nicotinate phosphoribosyltransferase
  NIMA related kinase 2
  NOP56 ribonucleoprotein
  NRAS proto-oncogene, GTPase
  nuclear receptor subfamily 2 group C member 2
  nuclear receptor subfamily 4 group A member 1
  nuclear RNA export factor 1
  nucleic acid binding protein 2
  nucleolar protein interacting with the FHA domain of MKI67
  nucleophosmin 1
  nucleoporin 214
  O-6-methylguanine-DNA methyltransferase
  obscurin like cytoskeletal adaptor 1
  ORMDL sphingolipid biosynthesis regulator 3
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  parkin RBR E3 ubiquitin protein ligase
  peptidylprolyl isomerase E
  perilipin 3
  phosphatidylinositol binding clathrin assembly protein
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphofructokinase, muscle
  phosphofructokinase, platelet
  phosphoglycerate dehydrogenase
  phosphoglycerate kinase 1
  phosphoinositide-3-kinase regulatory subunit 2
  phospholipase C gamma 1
  phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  phytanoyl-CoA 2-hydroxylase interacting protein
  plasminogen activator, urokinase receptor
  platelet activating factor acetylhydrolase 1b catalytic subunit 3
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 3
  poly(A) binding protein cytoplasmic 4
  poly(rC) binding protein 1
  poly(rC) binding protein 2
  poly(U) binding splicing factor 60
  polyglutamine binding protein 1
  polysaccharide biosynthesis domain containing 1
  potassium channel tetramerization domain containing 10
  potassium voltage-gated channel subfamily E regulatory subunit 3
  POU class 5 homeobox 1
  pregnancy specific beta-1-glycoprotein 9
  profilin 2
  progestagen associated endometrial protein
  prohibitin
  proliferating cell nuclear antigen
  proteasome 20S subunit alpha 2
  proteasome 20S subunit alpha 3
  proteasome 20S subunit alpha 6
  proteasome 20S subunit beta 4
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 14
  protein arginine methyltransferase 8
  protein kinase C delta
  protein kinase C zeta
  protein kinase D2
  protein kinase N2
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 4 catalytic subunit
  protein tyrosine phosphatase non-receptor type 4
  protein tyrosine phosphatase receptor type C associated protein
  protein tyrosine phosphatase receptor type F
  protocadherin alpha 4
  PTEN induced kinase 1
  pyruvate dehydrogenase E1 subunit beta
  pyruvate kinase M1/2
  RAB27A, member RAS oncogene family
  RAB2A, member RAS oncogene family
  RAB7A, member RAS oncogene family
  Rac family small GTPase 1
  RAD18 E3 ubiquitin protein ligase
  RAD23 homolog A, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  RAD52 homolog, DNA repair protein
  Raf-1 proto-oncogene, serine/threonine kinase
  RAN binding protein 2
  RAN binding protein 9
  RAP2A, member of RAS oncogene family
  RAS related
  RB binding protein 8, endonuclease
  receptor for activated C kinase 1
  RecQ like helicase 4
  regulator of G protein signaling 12
  replication factor C subunit 5
  replication protein A1
  replication protein A2
  replication protein A3
  Rho family GTPase 1
  ribosomal protein L10 like
  ribosomal protein L10a
  ribosomal protein L11
  ribosomal protein L12
  ribosomal protein L15
  ribosomal protein L17
  ribosomal protein L18
  ribosomal protein L18a
  ribosomal protein L21
  ribosomal protein L23a
  ribosomal protein L24
  ribosomal protein L3
  ribosomal protein L30
  ribosomal protein L31
  ribosomal protein L4
  ribosomal protein L5
  ribosomal protein L6
  ribosomal protein L7
  ribosomal protein L7a
  ribosomal protein L9
  ribosomal protein lateral stalk subunit P0
  ribosomal protein lateral stalk subunit P1
  ribosomal protein S11
  ribosomal protein S13
  ribosomal protein S14
  ribosomal protein S15a
  ribosomal protein S16
  ribosomal protein S19
  ribosomal protein S2
  ribosomal protein S23
  ribosomal protein S24
  ribosomal protein S27
  ribosomal protein S3A
  ribosomal protein S4 X-linked
  ribosomal protein S5
  ribosomal protein S6
  ribosomal protein S6 kinase B2
  ribosomal protein S8
  ribosomal protein SA
  ribosome binding protein 1
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 10
  ring finger protein 123
  ring finger protein 138
  ring finger protein 31
  ring-box 1
  RIO kinase 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 3
  RNA binding motif protein 4
  RNA binding motif protein X-linked
  RNA polymerase I subunit A
  RNA polymerase II subunit A
  RNA polymerase II subunit B
  RNA polymerase II subunit C
  RNA polymerase II, I and III subunit E
  RNA polymerase III subunit B
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  salt inducible kinase 1
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  secreted phosphoprotein 1
  SEM1 26S proteasome complex subunit
  septin 2
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 11
  serine/arginine repetitive matrix 2
  serpin family B member 5
  serpin family B member 9
  seryl-tRNA synthetase 2, mitochondrial
  sex hormone binding globulin
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  signal sequence receptor subunit 1
  signal transducer and activator of transcription 6
  single stranded DNA binding protein 1
  sirtuin 6
  SMAD family member 2
  SMAD family member 4
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein 13
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein polypeptide A
  small RNA binding exonuclease protection factor La
  small ubiquitin like modifier 2
  snail family transcriptional repressor 1
  SNW domain containing 1
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  SPT16 homolog, facilitates chromatin remodeling subunit
  stathmin 2
  staufen double-stranded RNA binding protein 1
  stratifin
  striatin 4
  succinate dehydrogenase complex assembly factor 2
  sulfotransferase family 1E member 1
  SUMO specific peptidase 2
  survival of motor neuron 1, telomeric
  synuclein alpha
  TAR DNA binding protein
  TATA-box binding protein associated factor 9
  tet methylcytosine dioxygenase 2
  TGFB induced factor homeobox 1
  thioredoxin like 1
  thymidine kinase 1
  thymosin, beta 4, X chromosome
  thyroid hormone receptor associated protein 3
  thyroid hormone receptor interactor 4
  TNF receptor associated factor 6
  TNF receptor associated protein 1
  TNF superfamily member 11
  TNFAIP3 interacting protein 2
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  TRAF3 interacting protein 1
  transcription factor CP2
  transforming growth factor beta 1
  transmembrane protein 41B
  transmembrane serine protease 3
  transthyretin
  tripartite motif containing 25
  tripartite motif containing 29
  tryptophanyl-tRNA synthetase 1
  tubulin alpha 1c
  tubulin alpha 4a
  tubulin beta class I
  tubulin gamma 1
  tubulin gamma complex associated protein 2
  tubulin tyrosine ligase like 12
  tudor domain containing 3
  tumor necrosis factor
  tumor protein p53
  tumor protein p53 binding protein 2
  tumor protein p63
  tumor protein, translationally-controlled 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosyl-tRNA synthetase 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 4
  ubiquinol-cytochrome c reductase hinge protein
  ubiquitin conjugating enzyme E2 M
  ubiquitin D
  ubiquitin like 4A
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 18
  unk zinc finger
  vacuolar protein sorting 13 homolog A
  valyl-tRNA synthetase 1
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  WT1 associated protein
  Y-box binding protein 1
  Yes1 associated transcriptional regulator
  YY1 associated factor 2
  zinc finger and BTB domain containing 16
  zinc finger and BTB domain containing 7A
  zinc finger CCHC-type containing 10
  zinc finger DHHC-type palmitoyltransferase 17
  zinc finger protein 24
  ZPR1 zinc finger
  ZPR1 zinc finger

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.