CDK9, cyclin dependent kinase 9

CDK9, cyclin dependent kinase 9

• The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]

• Gene Synonyms (cyclin-dependent kinase 9, CDC2-related kinase, cell division cycle 2-like protein kinase 4, cell division protein kinase 9, serine/threonine protein kinase PITALRE, tat-associated kinase complex catalytic subunit, C-2k, CDC2L4, CTK1, PITALRE, TAK,)
• NCBI Gene ID: 1025
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R880
  UNIPROT ID#>>P50750
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cyclin dependent kinase 9 interacts with:

• 5'-3' exoribonuclease 2
  actin beta like 2
  actin binding LIM protein 1
  actin related protein 2/3 complex subunit 3
  actin related protein 2/3 complex subunit 4
  actin related protein 2/3 complex subunit 5 like
  actin related protein 3
  activator of HSP90 ATPase activity 1
  AF4/FMR2 family member 1
  AF4/FMR2 family member 3
  AF4/FMR2 family member 4
  AF4/FMR2 family, member 1
  AHNAK nucleoprotein 2
  aldo-keto reductase family 1 member B10
  aldo-keto reductase family 1 member C3
  Aly/REF export factor
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis inducing factor mitochondria associated 1
  apoptotic chromatin condensation inducer 1
  aryl hydrocarbon receptor interacting protein
  ATP binding cassette subfamily D member 3
  ATP binding cassette subfamily F member 2
  ATPase family AAA domain containing 3A
  ATPase H+ transporting V1 subunit H
  ATR interacting protein
  AT-rich interaction domain 3B
  autophagy related 16 like 1
  BAF nuclear assembly factor 1
  BCL10 immune signaling adaptor
  BMS1 ribosome biogenesis factor
  bromodomain containing 4
  calcium/calmodulin dependent serine protein kinase
  casein kinase 1 alpha 1
  casein kinase 2 alpha 1
  casein kinase 2 beta
  catechol-O-methyltransferase
  catenin alpha 1
  catenin beta 1
  CCAAT enhancer binding protein beta
  CCR4-NOT transcription complex subunit 9
  CDC42 binding protein kinase alpha
  cell cycle and apoptosis regulator 2
  cell division cycle 37, HSP90 cochaperone
  cell division cycle 7
  cell division cycle 73
  centromere protein A
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 8
  checkpoint kinase 1
  chromobox 3
  citron rho-interacting serine/threonine kinase
  claspin
  clathrin heavy chain
  cleavage stimulation factor subunit 3
  cofilin 1
  coiled-coil domain containing 120
  coiled-coil domain containing 87
  COPI coat complex subunit beta 2
  coronin 1C
  cortactin
  CTD phosphatase subunit 1
  CTD small phosphatase like
  CTR9 homolog, Paf1/RNA polymerase II complex component
  cullin 1
  cyclin dependent kinase 12
  cyclin dependent kinase 15
  cyclin dependent kinase 5 regulatory subunit 1
  cyclin dependent kinase 9
  cyclin dependent kinase inhibitor 1C
  cyclin K
  cysteine and glycine rich protein 1
  cytoskeleton associated protein 5
  DEAD-box helicase 17
  DEAD-box helicase 24
  DEAD-box helicase 27
  DEAD-box helicase 3 X-linked
  DEAD-box helicase 5
  dedicator of cytokinesis 5
  deoxythymidylate kinase
  destrin, actin depolymerizing factor
  DExD-box helicase 21
  DExD-box helicase 39A
  DExH-box helicase 9
  dihydrolipoamide dehydrogenase
  DnaJ heat shock protein family (Hsp40) member B12
  dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
  double PHD fingers 2
  drebrin 1
  dynamin 2
  E1A binding protein p300
  egl-9 family hypoxia inducible factor 3
  EH domain containing 2
  ELAV like RNA binding protein 1
  ELL associated factor 1
  elongation factor for RNA polymerase II
  elongation factor for RNA polymerase II 2
  elongation factor Tu GTP binding domain containing 2
  EMAP like 4
  emerin
  enhancer of mRNA decapping 4
  estrogen receptor 2
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 alpha 2
  eukaryotic translation elongation factor 1 beta 2
  eukaryotic translation elongation factor 1 delta
  eukaryotic translation initiation factor 2 subunit gamma
  eukaryotic translation initiation factor 4 gamma 1
  eukaryotic translation initiation factor 4 gamma 2
  eukaryotic translation initiation factor 4E
  EWS RNA binding protein 1
  exosome component 3
  exosome component 4
  exosome component 5
  far upstream element binding protein 1
  far upstream element binding protein 3
  F-box and leucine rich repeat protein 19
  F-box protein 25
  ferritin light chain
  FGR proto-oncogene, Src family tyrosine kinase
  fibroblast growth factor receptor 1
  fibroblast growth factor receptor 4
  filamin A
  filamin B
  FKBP prolyl isomerase 3
  FKBP prolyl isomerase 5
  FLII actin remodeling protein
  FtsJ RNA 2'-O-methyltransferase 3
  FUS RNA binding protein
  G protein subunit beta 2
  G3BP stress granule assembly factor 2
  GATA binding protein 4
  GATA binding protein 6
  gelsolin
  general transcription factor IIF subunit 1
  glucosidase II alpha subunit
  glutamine--fructose-6-phosphate transaminase 1
  glutathione synthetase
  glyceraldehyde-3-phosphate dehydrogenase
  granulin precursor
  H1.3 linker histone, cluster member
  H1.4 linker histone, cluster member
  H2A clustered histone 18
  H2A.X variant histone
  H2B clustered histone 1
  H2B clustered histone 13
  H2B clustered histone 21
  H3 clustered histone 1
  H3 clustered histone 14
  H4 clustered histone 1
  H4 clustered histone 14
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 2
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 6
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heat shock protein family B (small) member 1
  heat shock protein family D (Hsp60) member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  helicase like transcription factor
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein C
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein L
  heterogeneous nuclear ribonucleoprotein M
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U
  HEXIM P-TEFb complex subunit 1
  HEXIM P-TEFb complex subunit 2
  high mobility group box 3
  histidine triad nucleotide binding protein 1
  histone deacetylase 4
  HIV-1 Tat specific factor 1
  hypoxia inducible factor 1 subunit alpha
  ILK associated serine/threonine phosphatase
  IMP U3 small nucleolar ribonucleoprotein 3
  inhibitor of growth family member 5
  inner membrane mitochondrial protein
  insulin like growth factor 2 mRNA binding protein 1
  insulin like growth factor 2 mRNA binding protein 2
  interleukin 6 signal transducer
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  IQ motif containing GTPase activating protein 1
  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
  isoleucyl-tRNA synthetase 1
  karyopherin subunit alpha 2
  karyopherin subunit beta 1
  keratin 10
  keratin 18
  keratin 19
  keratin 2
  keratin 7
  keratin 8
  KH-type splicing regulatory protein
  kinesin family member 5B
  kinesin light chain 4
  La ribonucleoprotein 1, translational regulator
  La ribonucleoprotein 4
  La ribonucleoprotein 7, transcriptional regulator
  ladybird homeobox 2
  lamin B receptor
  lamin B1
  LanC like 2
  leucine rich repeat containing 59
  LIM and SH3 protein 1
  LIM domain 7
  LRR binding FLII interacting protein 2
  lysine methyltransferase 2A
  maestro heat like repeat family member 7
  major histocompatibility complex, class I, A
  matrin 3
  MDM2 proto-oncogene
  mediator complex subunit 1
  mediator complex subunit 12
  mediator complex subunit 21
  mediator complex subunit 26
  mediator complex subunit 28
  methionyl-tRNA synthetase 1
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
  methylphosphate capping enzyme
  methyltransferase like 3
  microsomal glutathione S-transferase 1
  microtubule associated protein 4
  mitochondrial ribosomal protein L12
  mitochondrial ribosomal protein L41
  mitochondrial ribosomal protein S14
  mitochondrial ribosomal protein S27
  mitogen-activated protein kinase kinase 2
  mitogen-activated protein kinase kinase 3
  MLLT1 super elongation complex subunit
  MLLT3 super elongation complex subunit
  moesin
  MSL complex subunit 1
  MSL complex subunit 2
  mutL homolog 1
  mutS homolog 2
  MYB proto-oncogene like 2
  MYC proto-oncogene, bHLH transcription factor
  myelin basic protein
  myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
  MyoD family inhibitor domain containing
  myosin heavy chain 10
  myosin heavy chain 14
  myosin heavy chain 9
  myosin IC
  myosin ID
  myosin IE
  myosin light chain 12A
  myosin light chain 12B
  myosin light chain 6
  myosin VA
  myosin XVIIIA
  NDUFA4 mitochondrial complex associated
  nibrin
  NLR family pyrin domain containing 1
  non-POU domain containing octamer binding
  NOP2 nucleolar protein
  NOP2/Sun RNA methyltransferase 2
  nuclear factor kappa B subunit 1
  nuclear FMR1 interacting protein 1
  nuclear mitotic apparatus protein 1
  nuclear transcription factor, X-box binding 1
  nucleolar protein 7
  nucleolin
  nucleophosmin 1
  nucleophosmin/nucleoplasmin 3
  nucleoporin 107
  nucleoporin 155
  nucleoporin 205
  nucleoporin 214
  nucleoporin 35
  nucleoporin 98 and 96 precursor
  OPA1 mitochondrial dynamin like GTPase
  oxidative stress responsive kinase 1
  PAF1 homolog, Paf1/RNA polymerase II complex component
  PAX interacting protein 1
  pelota mRNA surveillance and ribosome rescue factor
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  peptidylprolyl isomerase A
  peroxiredoxin 1
  peroxiredoxin 2
  phosphatidylinositol binding clathrin assembly protein
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphofructokinase, liver type
  phosphoglycerate dehydrogenase
  pinin, desmosome associated protein
  plastin 3
  platelet derived growth factor receptor alpha
  plectin
  PMS1 homolog 1, mismatch repair system component
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein nuclear 1
  poly(rC) binding protein 1
  poly(rC) binding protein 2
  polypyrimidine tract binding protein 1
  praja ring finger ubiquitin ligase 2
  profilin 1
  progastricsin
  programmed cell death 11
  proline rich coiled-coil 2C
  prolyl 4-hydroxylase subunit alpha 1
  prolyl 4-hydroxylase subunit beta
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, non-ATPase 4
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 regulatory subunit 12A
  protein phosphatase 1 regulatory subunit 9B
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 5 catalytic subunit
  pyruvate dehydrogenase E1 subunit alpha 1
  pyruvate kinase M1/2
  RAD21 cohesin complex component
  RALY heterogeneous nuclear ribonucleoprotein
  RAN, member RAS oncogene family
  RB transcriptional corepressor 1
  receptor for activated C kinase 1
  receptor tyrosine kinase like orphan receptor 1
  RecQ like helicase 4
  RELA proto-oncogene, NF-kB subunit
  replication factor C subunit 3
  replication factor C subunit 4
  required for meiotic nuclear division 5 homolog B
  ribonucleotide reductase regulatory subunit M2
  ribophorin I
  ribophorin II
  ribosomal protein L10a
  ribosomal protein L13
  ribosomal protein L15
  ribosomal protein L17
  ribosomal protein L18
  ribosomal protein L18a
  ribosomal protein L21
  ribosomal protein L23
  ribosomal protein L23a
  ribosomal protein L24
  ribosomal protein L26 like 1
  ribosomal protein L27a
  ribosomal protein L28
  ribosomal protein L30
  ribosomal protein L31
  ribosomal protein L35
  ribosomal protein L4
  ribosomal protein L6
  ribosomal protein L7
  ribosomal protein L7a
  ribosomal protein lateral stalk subunit P0
  ribosomal protein lateral stalk subunit P1
  ribosomal protein S10
  ribosomal protein S11
  ribosomal protein S13
  ribosomal protein S15
  ribosomal protein S15a
  ribosomal protein S16
  ribosomal protein S17
  ribosomal protein S18
  ribosomal protein S19
  ribosomal protein S2
  ribosomal protein S20
  ribosomal protein S25
  ribosomal protein S26
  ribosomal protein S27
  ribosomal protein S3
  ribosomal protein S3A
  ribosomal protein S4 X-linked
  ribosomal protein S5
  ribosomal protein S6
  ribosomal protein S7
  ribosomal protein S8
  ribosomal protein S9
  ribosomal RNA processing 15 homolog
  ribosome binding protein 1
  ribosome biogenesis regulator 1 homolog
  ring finger and CHY zinc finger domain containing 1
  ring finger protein 20
  ring finger protein 40
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 14
  RNA binding motif protein 27
  RNA binding motif protein 34
  RNA binding motif protein 39
  RNA polymerase II subunit A
  RNA terminal phosphate cyclase like 1
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  S100 calcium binding protein A10
  SAFB like transcription modulator
  scaffold attachment factor B
  SEC31 homolog A, COPII coat complex component
  septin 11
  septin 9
  sequestosome 1
  serine and arginine rich splicing factor 7
  serine and arginine rich splicing factor 9
  serine/arginine repetitive matrix 2
  serine/threonine kinase 26
  serine/threonine kinase 36
  SERPINE1 mRNA binding protein 1
  SET domain containing 1B, histone lysine methyltransferase
  sideroflexin 1
  signal induced proliferation associated 1 like 1
  signal induced proliferation associated 1 like 3
  signal recognition particle 14
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  sirtuin 7
  Ski2 like RNA helicase
  SMAD family member 1
  SMAD family member 2
  SMAD family member 3
  SMAD family member 4
  small nuclear ribonucleoprotein 13
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein polypeptide E
  small nuclear ribonucleoprotein U1 subunit 70
  Snf2 related CREBBP activator protein
  SNW domain containing 1
  solute carrier family 25 member 1
  solute carrier family 25 member 22
  solute carrier family 25 member 3
  spectrin alpha, non-erythrocytic 1
  spectrin beta, non-erythrocytic 1
  S-phase kinase associated protein 1
  S-phase kinase associated protein 2
  spliceosome associated factor 3, U4/U6 recycling protein
  splicing factor 3a subunit 1
  splicing factor 3a subunit 3
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  splicing factor proline and glutamine rich
  SPT16 homolog, facilitates chromatin remodeling subunit
  SPT5 homolog, DSIF elongation factor subunit
  SRA stem-loop interacting RNA binding protein
  staufen double-stranded RNA binding protein 1
  stress induced phosphoprotein 1
  structural maintenance of chromosomes 2
  structural maintenance of chromosomes 3
  structural maintenance of chromosomes 4
  structure specific recognition protein 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  TAL bHLH transcription factor 1, erythroid differentiation factor
  TAR DNA binding protein
  TATA-box binding protein associated factor 15
  TATA-box binding protein associated factor 7
  telomeric repeat binding factor 1
  telomeric repeat binding factor 2
  thymopoietin
  thyroid hormone receptor interactor 12
  tight junction protein 1
  TNF receptor associated factor 2
  TNF receptor associated protein 1
  transcription elongation factor A1
  transformed mouse 3T3 cell double minute 2
  transforming growth factor beta 1
  transgelin 2
  translocated promoter region, nuclear basket protein
  transmembrane protein 33
  treacle ribosome biogenesis factor 1
  tripartite motif containing 14
  tripartite motif containing 28
  tripartite motif containing 33
  tropomodulin 3
  tropomyosin 1
  tropomyosin 2
  tropomyosin 3
  tropomyosin 4
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin beta 3 class III
  tubulin beta 4B class IVb
  tubulin beta 6 class V
  tubulin beta class I
  tubulin folding cofactor B
  tumor protein p53
  twinfilin actin binding protein 1
  ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
  ubiquitin conjugating enzyme E2 A
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 S
  ubiquitin like 4A
  ubiquitin protein ligase E3 component n-recognin 5
  unc-45 myosin chaperone A
  valyl-tRNA synthetase 1
  VAMP associated protein A
  villin 1
  vimentin
  voltage dependent anion channel 2
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 3
  X-ray repair cross complementing 6
  Y-box binding protein 1
  Y-box binding protein 3
  YES proto-oncogene 1, Src family tyrosine kinase
  zinc finger CCCH-type containing 13
  zinc finger MYM-type containing 6
  zinc finger protein 638

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.